Physical and psychological predictors of quality of life in Chinese colorectal cancer patients during chemotherapy

Zhang, Meifen, Peng, Lifen, Liu, Weiyan, Wen, Yongshan, Wu, Xiaodan, Zheng, Meichun, Zhu, Yaping, Liu, Qianwen and Chan, Sally (2014) Physical and psychological predictors of quality of life in Chinese colorectal cancer patients during chemotherapy. Cancer Nursing, . doi:10.1097/NCC.0000000000000190

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Author Zhang, Meifen
Peng, Lifen
Liu, Weiyan
Wen, Yongshan
Wu, Xiaodan
Zheng, Meichun
Zhu, Yaping
Liu, Qianwen
Chan, Sally
Title Physical and psychological predictors of quality of life in Chinese colorectal cancer patients during chemotherapy
Journal name Cancer Nursing   Check publisher's open access policy
ISSN 0162-220X
1538-9804
Publication date 2014-05-29
Year available 2014
Sub-type Article (original research)
DOI 10.1097/NCC.0000000000000190
Open Access Status
Total pages 10
Place of publication Philadelphia, PA, United States
Publisher Lippincott Williams & Wilkins
Collection year 2015
Language eng
Formatted abstract
Background: Maintaining quality of life (QOL) during chemotherapy is a critical aspect of cancer treatment. Instruments have been developed to assess symptom distress, self-efficacy, anxiety, depression, and other factors impacting QOL during cancer treatment, but Chinese versions have become available only recently.
Objective: The aim of this study was to identify factors predictive of QOL during chemotherapy in Chinese colorectal cancer (CRC) patients.
Methods: Patients completed Chinese versions of the Hospital Anxiety and Depression Scale, MD Anderson Symptom Inventory (a measure of symptom distress), Stanford Inventory of Cancer Patient Adjustment (a measure of self-efficacy), and Functional Assessment of Cancer Treatment-General (a measure of QOL) before and after 3 and 6 months of chemotherapy.
Results: Of 152 consecutive CRC patients (men/women, 98/54; mean age, 53.3 ± 11.3 years, 25-75 years; stage II/III, 59/93), 121 completed all questionnaires (79.6%). Self-efficacy dimensions "communication," "activity management," "personal management," and "affective management" improved progressively over 6 months (all P <.05). Fatigue, nausea, lack of appetite, disturbed sleep, and vomiting peaked at 3 months and declined thereafter (P <.05). Patients who are younger than 60 years, are male, and with stage II CRC exhibited higher 3- and 6-month QOL scores (all P <.05). Multiple regression identified self-efficacy, anxiety, and symptom distress as independent predictors of QOL at 6 months.
Conclusions: Enhanced self-efficacy, reduced symptom distress, and lower general anxiety would improve QOL during chemotherapy for CRC patients.These instruments can help identify CRC patients at risk of low QOL for additional psychotherapy or specific treatment modifications.
Keyword Anxiety
Chinese patient
Colorectal cancer
Depression
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Nursing, Midwifery and Social Work Publications
 
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Created: Wed, 10 Sep 2014, 11:23:43 EST by Vicki Percival on behalf of School of Nursing, Midwifery and Social Work