Outbreaks of multidrug-resistant Acinetobacter baumannii strains in a Kenyan teaching hospital

Huber, Charlotte A., Sartor, Anna L., McOdimba, Francis, Shah, Reena, Shivachi, Patricia, Sidjabat, Hanna E., Revathi, Gunturu and Paterson, David L. (2014) Outbreaks of multidrug-resistant Acinetobacter baumannii strains in a Kenyan teaching hospital. Journal of Global Antimicrobial Resistance, 2 3: 190-193. doi:10.1016/j.jgar.2014.03.007

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Author Huber, Charlotte A.
Sartor, Anna L.
McOdimba, Francis
Shah, Reena
Shivachi, Patricia
Sidjabat, Hanna E.
Revathi, Gunturu
Paterson, David L.
Title Outbreaks of multidrug-resistant Acinetobacter baumannii strains in a Kenyan teaching hospital
Journal name Journal of Global Antimicrobial Resistance   Check publisher's open access policy
ISSN 2213-7165
2213-7173
Publication date 2014-09
Year available 2014
Sub-type Article (original research)
DOI 10.1016/j.jgar.2014.03.007
Open Access Status
Volume 2
Issue 3
Start page 190
End page 193
Total pages 4
Place of publication Amsterdam, The Netherlands
Publisher Elsevier B V
Collection year 2015
Language eng
Subject 2403 Immunology
2404 Microbiology
2723 Immunology and Allergy
2726 Microbiology (medical)
Abstract Acinetobacter baumannii is a serious nosocomial pathogen with a high propensity to cause outbreaks. Whilst outbreaks of A. baumannii have been reported in many regions worldwide, few data are available from East Africa. In this study, 25 A. baumannii isolates derived from a single institution located in Nairobi, Kenya, between September 2010 and September 2011 were examined. Antimicrobial susceptibility testing was performed by the disc diffusion method and the relatedness among the isolates was examined by pulsed-field gel electrophoresis, repetitive sequence-based PCR (rep-PCR) and multilocus sequence typing. The examined isolates clustered into three distinct groups. The most prevalent sequence type (ST) was ST110 (17 isolates), followed by ST92 (5 isolates) and ST109 (3 isolates). All isolates exhibited resistance to cefepime, ceftazidime, ticarcillin/clavulanic acid, cefotaxime/clavulanic acid, piperacillin/tazobactam, cefoxitin, ciprofloxacin, gentamicin, nitrofurantoin, fosfomycin trometamol, trimethoprim/sulfamethoxazole, amikacin, meropenem and imipenem, with the exception of four isolates. Two isolates belonging to ST92 and two isolates belonging to ST109 were susceptible to amikacin; one of these amikacin-susceptible ST109 isolates was also susceptible to meropenem and imipenem. All isolates were positive for OXA 51-like and all carbapenem-resistant isolates were OXA-23 positive.
Keyword Acinetobacter baumannii
Antibiotic susceptibility
Outbreak
Sequence type
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2015 Collection
 
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