Targeting the IL-12/IL-23 axis: an alternative approach to removing tumor induced immune suppression

Smyth, Mark J. and Teng, Michele W. L. (2014) Targeting the IL-12/IL-23 axis: an alternative approach to removing tumor induced immune suppression. Oncoimmunology, 3 e28964.1-e28964.2. doi:10.4161/onci.28964


Author Smyth, Mark J.
Teng, Michele W. L.
Title Targeting the IL-12/IL-23 axis: an alternative approach to removing tumor induced immune suppression
Journal name Oncoimmunology   Check publisher's open access policy
ISSN 2162-4011
2162-402X
Publication date 2014-05
Sub-type Editorial
DOI 10.4161/onci.28964
Open Access Status Not Open Access
Volume 3
Start page e28964.1
End page e28964.2
Total pages 2
Place of publication Austin, TX, United States
Publisher Landes Bioscience
Language eng
Abstract Combination immune checkpoint blockade has demonstrated significant clinical responses in cancers infiltrated by T cells. Many tumors contain high proportions of myeloid cells and these can secrete immunosuppressive cytokines like IL-23. Our data suggest the clinical potential of using anti-CD40 (push) and anti-IL-23 mAbs (pull) to tip the IL-12/23 balance in established tumors and act as an alternative combination cancer immunotherapy.
Keyword Cancer
Immunotherapy
Tumor-induced immune suppression
Anti-CD40
Anti-IL-23
Q-Index Code CX
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Editorial
Collection: School of Medicine Publications
 
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