Structural model of human IL-13 defines the spatial interactions with the IL-13Rα/IL-4Rα receptor

Zuegg, J., Webb, D. C., Foster, P. S. and Casarotto, M. G. (2001) Structural model of human IL-13 defines the spatial interactions with the IL-13Rα/IL-4Rα receptor. Immunology and Cell Biology, 79 4: 332-339. doi:10.1046/j.1440-1711.2001.01035.x


Author Zuegg, J.
Webb, D. C.
Foster, P. S.
Casarotto, M. G.
Title Structural model of human IL-13 defines the spatial interactions with the IL-13Rα/IL-4Rα receptor
Journal name Immunology and Cell Biology   Check publisher's open access policy
ISSN 0818-9641
1440-1711
Publication date 2001-01-01
Sub-type Article (original research)
DOI 10.1046/j.1440-1711.2001.01035.x
Open Access Status Not yet assessed
Volume 79
Issue 4
Start page 332
End page 339
Total pages 8
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Formatted abstract
Interleukin-13 (IL-13) plays a key role in immune responses and inflammation. A structural model of human IL-13 (HuIL-13) based on the nuclear magnetic resonance and X-ray structure of IL-4 is put forward. Unlike previous models, this model is based on new sequence alignments that take into account the formation of the two disulfide linkages that have been determined experimentally. The proposed structure of human IL-13 is similar to IL-4, consisting of a four helix bundle with hydrophobic residues lining the core of the molecule and surface polar residues showing a high degree of solvent accessibility. Regions of HuIL-13 that are critical for the interaction with its receptors are explored and discussed in relation to existing mutagenic studies. From these studies we predict that helices A and C of HuIL-13 interact with the IL-4 receptor alpha (IL-4Rα) region and helix D is responsible for the interaction with the IL-13 receptor alpha 1 (IL-13Rα 1) receptor.
Keyword Asthma
Cytokine
Homology modelling
Interleukin-13
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Molecular Bioscience - Publications
 
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