An Update on GABAρ Receptors

Martínez-Delgado, Gustavo, Estrada-Mondragon, Argel, Miledi, Ricardo and Martínez-Torres, Ataúlfo (2010) An Update on GABAρ Receptors. Current Neuropharmacology, 8 4: 422-433. doi:10.2174/157015910793358141

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Author Martínez-Delgado, Gustavo
Estrada-Mondragon, Argel
Miledi, Ricardo
Martínez-Torres, Ataúlfo
Title An Update on GABAρ Receptors
Journal name Current Neuropharmacology   Check publisher's open access policy
ISSN 1875-6190
Publication date 2010-12
Sub-type Critical review of research, literature review, critical commentary
DOI 10.2174/157015910793358141
Open Access Status
Volume 8
Issue 4
Start page 422
End page 433
Total pages 12
Place of publication Bussum, Netherlands
Publisher Bentham Science Publishers
Language eng
Abstract The present review discusses the functional and molecular diversity of GABA rho receptors. These receptors were originally described in the mammalian retina, and their functional role in the visual pathway has been recently elucidated; however new studies on their distribution in the brain and spinal cord have revealed that they are more spread than originally thought, and thus it will be important to determine their physiological contribution to the GABAergic trans-mission in other areas of the central nervous system. In addition, molecular modeling has revealed peculiar traits of these receptors that have impacted on the interpretations of the latest pharmacolgical and biophysical findings. Finally, sequencing of several vertebrate genomes has permitted a comparative analysis of the organization of the GABA rho genes.
Keyword GABA receptor gene organization
Ligand Gated Ion Channel
Receptor structure
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: Queensland Brain Institute Publications
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Citation counts: TR Web of Science Citation Count  Cited 12 times in Thomson Reuters Web of Science Article | Citations
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Created: Thu, 04 Sep 2014, 08:49:44 EST by Argel Estrada on behalf of Queensland Brain Institute