Rational design and synthesis of SERS labels

Wang, Yuling and Schluecker, Sebastian (2013) Rational design and synthesis of SERS labels. Analyst, 138 8: 2224-2238. doi:10.1039/c3an36866a

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Author Wang, Yuling
Schluecker, Sebastian
Title Rational design and synthesis of SERS labels
Journal name Analyst   Check publisher's open access policy
ISSN 0003-2654
Publication date 2013
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1039/c3an36866a
Open Access Status File (Publisher version)
Volume 138
Issue 8
Start page 2224
End page 2238
Total pages 15
Place of publication Cambridge United Kingdom
Publisher R S C Publications
Language eng
Formatted abstract
SERS labels are a new class of nanotags for optical detection based on Raman scattering. Central advantages include their spectral multiplexing capacity due to the small line width of vibrational Raman bands, quantification based on spectral intensities, high photostability, minimization of autofluorescence from biological specimens via red to near-infrared (NIR) excitation, and the need for only a single laser excitation line. Current concepts for the rational design and synthesis of SERS labels are summarized in this review. Chemical constituents of SERS labels are the plasmonically active metal colloids for signal enhancement upon resonant laser excitation, organic Raman reporter molecules for adsorption onto the metal surface for identification, and an optional protective shell. Different chemical approaches towards the synthesis of rationally designed SERS labels are highlighted, including also their subsequent bioconjugation.
Keyword Enhanced raman-scattering
Surface-plasmon resonance
Gold-nanoparticle dimers
Organic-inorganic nanoparticles
Vivo cancer-detection
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: Australian Institute for Bioengineering and Nanotechnology Publications
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Citation counts: TR Web of Science Citation Count  Cited 35 times in Thomson Reuters Web of Science Article | Citations
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