Nuclear targeting dynamics of gold nanoclusters for enhanced therapy of HER2 + breast cancer

Wang, Yuling, Chen, Jiji and Irudayaraj, Joseph (2011) Nuclear targeting dynamics of gold nanoclusters for enhanced therapy of HER2 + breast cancer. ACS Nano, 5 12: 9718-9725. doi:10.1021/nn2032177

Author Wang, Yuling
Chen, Jiji
Irudayaraj, Joseph
Title Nuclear targeting dynamics of gold nanoclusters for enhanced therapy of HER2 + breast cancer
Journal name ACS Nano   Check publisher's open access policy
ISSN 1936-0851
Publication date 2011-12-27
Year available 2011
Sub-type Article (original research)
DOI 10.1021/nn2032177
Open Access Status
Volume 5
Issue 12
Start page 9718
End page 9725
Total pages 8
Place of publication Washington, DC United States
Publisher American Chemical Society
Collection year 2011
Language eng
Subject 2200 Engineering
2500 Materials Science
3100 Physics and Astronomy
Abstract Recent advances in fluorescent metal nanoclusters have spurred tremendous interest in nanomedicine due to the ease of fabrication, excellent biocompatibility, and, more importantly, excellent wavelength-dependent tunability. Herein, we report our findings on fluorescent BSA-protected gold nanoclusters (AuNCs), ∼2 nm in size conjugated with Herceptin (AuNCs-Her), for specific targeting and nuclear localization in ErbB2 over-expressing breast cancer cells and tumor tissue as a novel fluorescent agent for simultaneous imaging and cancer therapy. More interestingly, we found that AuNCs-Her could escape the endolysosomal pathway and enter the nucleus of cancer cells to enhance the therapeutic efficacy of Herceptin. We elucidate the diffusion characteristics (diffusion time and number of diffusers) and concentration of the fluorescing clusters in the nucleus of live cells. Our findings also suggest that the nuclear localization effect of AuNCs-Her enhances the anticancer therapeutic efficacy of Herceptin as evidenced by the induction of DNA damage. This study not only discusses a new nanomaterial platform for nuclear delivery of drugs but also provides important insights on nuclear targeting for enhanced therapy.
Keyword DNA damage
Gold nanoclusters
Nuclear nanomedicine
Single particle characterization
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Australian Institute for Bioengineering and Nanotechnology Publications
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