The burden attributable to mental and substance use disorders as risk factors for suicide: findings from the Global Burden of Disease Study 2010

Ferrari, Alize J., Norman, Rosana E., Freedman, Greg, Baxter, Amanda J., Pirkis, Jane E., Harris, Meredith G., Page, Andrew, Carnahan, Emily, Degenhardt, Louisa, Vos, Theo and Whiteford, Harvey A. (2014) The burden attributable to mental and substance use disorders as risk factors for suicide: findings from the Global Burden of Disease Study 2010. PLoS One, 9 4: e91936.1-e91936.11. doi:10.1371/journal.pone.0091936


Author Ferrari, Alize J.
Norman, Rosana E.
Freedman, Greg
Baxter, Amanda J.
Pirkis, Jane E.
Harris, Meredith G.
Page, Andrew
Carnahan, Emily
Degenhardt, Louisa
Vos, Theo
Whiteford, Harvey A.
Title The burden attributable to mental and substance use disorders as risk factors for suicide: findings from the Global Burden of Disease Study 2010
Journal name PLoS One   Check publisher's open access policy
ISSN 1932-6203
Publication date 2014-04-02
Sub-type Article (original research)
DOI 10.1371/journal.pone.0091936
Open Access Status DOI
Volume 9
Issue 4
Start page e91936.1
End page e91936.11
Total pages 11
Place of publication San Francisco, CA, United States
Publisher Public Library of Science
Collection year 2015
Language eng
Formatted abstract
Background: The Global Burden of Disease Study 2010 (GBD 2010) identified mental and substance use disorders as the 5th leading contributor of burden in 2010, measured by disability adjusted life years (DALYs). This estimate was incomplete as it excluded burden resulting from the increased risk of suicide captured elsewhere in GBD 2010's mutually exclusive list of diseases and injuries. Here, we estimate suicide DALYs attributable to mental and substance use disorders.

Methods: Relative-risk estimates of suicide due to mental and substance use disorders and the global prevalence of each disorder were used to estimate population attributable fractions. These were adjusted for global differences in the proportion of suicide due to mental and substance use disorders compared to other causes then multiplied by suicide DALYs reported in GBD 2010 to estimate attributable DALYs (with 95% uncertainty).

Results: Mental and substance use disorders were responsible for 22.5 million (14.8-29.8 million) of the 36.2 million (26.5-44.3 million) DALYs allocated to suicide in 2010. Depression was responsible for the largest proportion of suicide DALYs (46.1% (28.0%-60.8%)) and anorexia nervosa the lowest (0.2% (0.02%-0.5%)). DALYs occurred throughout the lifespan, with the largest proportion found in Eastern Europe and Asia, and males aged 20-30 years. The inclusion of attributable suicide DALYs would have increased the overall burden of mental and substance use disorders (assigned to them in GBD 2010 as a direct cause) from 7.4% (6.2%-8.6%) to 8.3% (7.1%-9.6%) of global DALYs, and would have changed the global ranking from 5th to 3rd leading cause of burden.

Conclusions: Capturing the suicide burden attributable to mental and substance use disorders allows for more accurate estimates of burden. More consideration needs to be given to interventions targeted to populations with, or at risk for, mental and substance use disorders as an effective strategy for suicide prevention. 
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
Queensland Children's Medical Research Institute Publications
School of Public Health Publications
 
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Created: Tue, 02 Sep 2014, 11:56:44 EST by Nyree Divitini on behalf of School of Public Health