CREB activity modulates neural cell proliferation, midbrain-hindbrain organization and patterning in zebrafish

Dworkin S., Heath J.K., deJong-Curtain T.A., Hogan B.M., Lieschke G.J., Malaterre J., Ramsay R.G. and Mantamadiotis T. (2007) CREB activity modulates neural cell proliferation, midbrain-hindbrain organization and patterning in zebrafish. Developmental Biology, 307 1: 127-141. doi:10.1016/j.ydbio.2007.04.026


Author Dworkin S.
Heath J.K.
deJong-Curtain T.A.
Hogan B.M.
Lieschke G.J.
Malaterre J.
Ramsay R.G.
Mantamadiotis T.
Title CREB activity modulates neural cell proliferation, midbrain-hindbrain organization and patterning in zebrafish
Journal name Developmental Biology   Check publisher's open access policy
ISSN 0012-1606
Publication date 2007-07-01
Sub-type Article (original research)
DOI 10.1016/j.ydbio.2007.04.026
Volume 307
Issue 1
Start page 127
End page 141
Total pages 15
Language eng
Subject 1309 Developmental Biology
Abstract Neural stem/progenitor cells (NPCs) self-renew and differentiate, generating neuronal and non-neuronal (glial) cell lineages. Although a number of factors, including transcription factors, have been shown to be important in the regulation of NPC proliferation and differentiation, the precise molecular networks remain to be identified. The cAMP Response Element-Binding protein (CREB) is a transcription factor important for neuronal survival, differentiation and plasticity. Recent work suggests that CREB activation, via serine phosphorylation in the kinase inducible domain, is important for neurogenesis in the adult rodent brain. We sought to further investigate CREB function in neurogenesis, using the zebrafish (Danio rerio). Structural and functional analysis of the zebrafish CREB orthologue showed high conservation with mammalian CREB. Activated (phosphorylated) CREB (pCREB) was localised to all known proliferation zones in the adult zebrafish brain, including actively cycling cells. Furthermore, we found that modulating CREB activity during early zebrafish development caused significant defects in neural proliferation, midbrain-hindbrain organization and body patterning. These findings reveal broader and stage-specific physiological roles of CREB function during vertebrate neural development and proliferation. Crown Copyright
Keyword CREB
Midbrain-hindbrain boundary
Neurogenesis
Zebrafish
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
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Citation counts: TR Web of Science Citation Count  Cited 32 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 31 times in Scopus Article | Citations
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