Role of delta-like-4/notch in the formation and wiring of the lymphatic network in zebrafish

Geudens, Ilse, Herpers, Robert, Hermans, Karlien, Segura, Inmaculada, Ruiz De Almodovar, Carmen, Bussmann, Jeroen, De Smet, Frederik, Vandevelde, Wouter, Hogan, Benjamin M., Siekmann, Arndt, Claes, Filip, Moore, John C., Silvia Pistocchi, Anna, Loges, Sonja, Mazzone, Massimiliano, Mariggi, Giovanni, Bruyere, Francoise, Cotelli, Franco, Kerjaschki, Dontscho, Noel, Agnes, Foidart, Jean-Michel, Gerhardt, Holger, Ny, Annelii, Langenberg, Tobias, Lawson, Nathan D., Duckers, Hendricus J., Schulte-Merker, Stefan, Carmeliet, Peter and Dewerchin, Mieke (2010) Role of delta-like-4/notch in the formation and wiring of the lymphatic network in zebrafish. Arteriosclerosis, Thrombosis, and Vascular Biology, 30 9: 1695-1702. doi:10.1161/ATVBAHA.110.203034

Author Geudens, Ilse
Herpers, Robert
Hermans, Karlien
Segura, Inmaculada
Ruiz De Almodovar, Carmen
Bussmann, Jeroen
De Smet, Frederik
Vandevelde, Wouter
Hogan, Benjamin M.
Siekmann, Arndt
Claes, Filip
Moore, John C.
Silvia Pistocchi, Anna
Loges, Sonja
Mazzone, Massimiliano
Mariggi, Giovanni
Bruyere, Francoise
Cotelli, Franco
Kerjaschki, Dontscho
Noel, Agnes
Foidart, Jean-Michel
Gerhardt, Holger
Ny, Annelii
Langenberg, Tobias
Lawson, Nathan D.
Duckers, Hendricus J.
Schulte-Merker, Stefan
Carmeliet, Peter
Dewerchin, Mieke
Title Role of delta-like-4/notch in the formation and wiring of the lymphatic network in zebrafish
Journal name Arteriosclerosis, Thrombosis, and Vascular Biology   Check publisher's open access policy
ISSN 1079-5642
Publication date 2010
Year available 2010
Sub-type Article (original research)
DOI 10.1161/ATVBAHA.110.203034
Open Access Status
Volume 30
Issue 9
Start page 1695
End page 1702
Total pages 8
Place of publication Philadelphia, PA United States
Publisher Lippincott Williams and Wilkins
Collection year 2010
Language eng
Subject 2705 Cardiology and Cardiovascular Medicine
Abstract Objective: To study whether Notch signaling, which regulates cell fate decisions and vessel morphogenesis, controls lymphatic development. Methods and Results: In zebrafish embryos, sprouts from the axial vein have lymphangiogenic potential because they give rise to the first lymphatics. Knockdown of delta-like-4 (Dll4) or its receptors Notch-1b or Notch-6 in zebrafish impaired lymphangiogenesis. Dll4/Notch silencing reduced the number of sprouts producing the string of parchordal lymphangioblasts; instead, sprouts connecting to the intersomitic vessels were formed. At a later phase, Notch silencing impaired navigation of lymphatic intersomitic vessels along their arterial templates. Conclusion: These studies imply critical roles for Notch signaling in the formation and wiring of the lymphatic network.
Keyword Gene silencing
Notch signaling
Vascular biology
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Molecular Bioscience - Publications
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