Zebrafish gcm2 is required for gill filament budding from pharyngeal ectoderm

Hogan B.M., Hunter M.P., Oates A.C., Crowhurst M.O., Hall N.E., Heath J.K., Prince V.E. and Lieschke G.J. (2004) Zebrafish gcm2 is required for gill filament budding from pharyngeal ectoderm. Developmental Biology, 276 2: 508-522. doi:10.1016/j.ydbio.2004.09.018

Author Hogan B.M.
Hunter M.P.
Oates A.C.
Crowhurst M.O.
Hall N.E.
Heath J.K.
Prince V.E.
Lieschke G.J.
Title Zebrafish gcm2 is required for gill filament budding from pharyngeal ectoderm
Journal name Developmental Biology   Check publisher's open access policy
ISSN 0012-1606
Publication date 2004-12-15
Sub-type Article (original research)
DOI 10.1016/j.ydbio.2004.09.018
Volume 276
Issue 2
Start page 508
End page 522
Total pages 15
Language eng
Subject 1309 Developmental Biology
Abstract The pharyngeal arches give rise to multiple organs critical for diverse processes, including the thymus, thyroid and parathyroids. Several molecular regulators of thymus and thyroid organogenesis are strikingly conserved between mammals and zebrafish. However, land animals have parathyroids whereas fish have gills. The murine transcription factor Glial cells missing 2 (Gcm2) is expressed specifically in the parathyroid primordium in the endodermal epithelium of the third pharyngeal pouch, and in both mice and humans is required for normal development of parathyroid glands. The molecular regulation of fish gill organogenesis remains to be described. We report the expression of gcm2 in the zebrafish pharyngeal epithelium and a requirement for Hox group 3 paralogs for gcm2 expression. Strikingly, zebrafish gcm2 is expressed in the ectodermal portion of the pharyngeal epithelium and is required for the development of the gill filament buds, precursors of fish-specific gill filaments. This study identifies yet another role for a GCM gene in embryonic development and indicates a role for gcm2 during the evolution of divergent pharyngeal morphologies.
Keyword Gill filament
Pharyngeal arch
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: ResearcherID Downloads
Scopus Import
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 37 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 39 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Fri, 29 Aug 2014, 18:44:53 EST by System User