New animal models of lymphangiogenesis

Hogan, Benjamin M. and Schulte-Merker, Stefan (2009). New animal models of lymphangiogenesis. In Steven A. Stacker and Marc G. Achen (Ed.), Lymphangiogenesis in cancer metastasis (pp. 27-54) Dordrecht Netherlands: Springer Netherlands. doi:10.1007/978-90-481-2247-9_3


Author Hogan, Benjamin M.
Schulte-Merker, Stefan
Title of chapter New animal models of lymphangiogenesis
Title of book Lymphangiogenesis in cancer metastasis
Place of Publication Dordrecht Netherlands
Publisher Springer Netherlands
Publication Year 2009
Sub-type Research book chapter (original research)
DOI 10.1007/978-90-481-2247-9_3
Open Access Status
Series Cancer Metastasis – Biology and Treatment
ISBN 978-90-481-2246-2
978-90-481-2247-9
ISSN 1568-2102
2215-1648
Editor Steven A. Stacker
Marc G. Achen
Volume number 13
Chapter number 3
Start page 27
End page 54
Total pages 28
Total chapters 10
Language eng
Formatted Abstract/Summary
The discovery of new genes, genetic pathways and drug targets involved in the formation of lymphatic vessels and capillaries has long been hampered by the absence of a small model organism amenable to large scale genetic and pharmacological screening. The recent description of functional and conserved lymphatic vascular systems in the two small animal models Xenopus laevis (the African clawed frog) and Danio rerio (the zebrafish) now opens up the possibility to exploit these models for the study of developmental lymphangiogenesis. In this chapter we will describe the discovery and characterisation of the lymphatic vasculature in both frog and fish models. We will also describe and compare the available genetic tools for the study of lymphangiogenesis in these new model systems.
Keyword Lymphatic
Vasculature
Lymphangiogenesis
Zebrafish
Xenopus
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Book Chapter
Collection: Institute for Molecular Bioscience - Publications
 
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