Cheilanthane sesterterpenes, protein kinase inhibitors, from a marine sponge of the genus Ircinia

Buchanan, Malcolm S., Edser, Annette, King, Gordon, Whitmore, Jacqueline and Quinn, Ronald J. (2001) Cheilanthane sesterterpenes, protein kinase inhibitors, from a marine sponge of the genus Ircinia. Journal of Natural Products, 64 3: 300-303. doi:10.1021/np0004597


Author Buchanan, Malcolm S.
Edser, Annette
King, Gordon
Whitmore, Jacqueline
Quinn, Ronald J.
Title Cheilanthane sesterterpenes, protein kinase inhibitors, from a marine sponge of the genus Ircinia
Formatted title
Cheilanthane sesterterpenes, protein kinase inhibitors, from a marine sponge of the genus Ircinia
Journal name Journal of Natural Products   Check publisher's open access policy
ISSN 0163-3864
1520-6025
Publication date 2001-03-01
Year available 2001
Sub-type Article (original research)
DOI 10.1021/np0004597
Open Access Status Not yet assessed
Volume 64
Issue 3
Start page 300
End page 303
Total pages 4
Place of publication Washington, DC, United States
Publisher American Chemical Society
Language eng
Formatted abstract
Four cheilanthane sesterterpenoids, 25-hydroxy-13(24),15,17-cheilanthatrien-19,25-olide 25-hydroxy-17-cheilanthen-19,25-olide (2), 25-hydroxy-13(24),17-cheilanthadien-16,19-olide (3), and (1), 13,16-epoxy-16,25-dihydroxy-13(24),17-cheilanthadien-19,25-olide (4), were isolated from the marine sponge Ircinia sp. Compounds 1, 3, and 4 are new natural products. The four compounds inhibit MSK1 (mitogen and stress activated kinase) and MAPKAPK-2 (mitogen activated protein kinase activated protein kinase), two protein kinases involved in mitogen and stress signal transduction.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Molecular Bioscience - Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 30 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 32 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Fri, 29 Aug 2014, 13:33:09 EST by System User on behalf of Learning and Research Services (UQ Library)