Current developments in MRI for assessing rodent models of multiple sclerosis

Alomair, Othman I., Smith, Maree T., Brereton, Ian M., Galloway, Graham J. and Kurniawan, Nyoman D. (2014) Current developments in MRI for assessing rodent models of multiple sclerosis. Future Neurology, 9 4: 487-511. doi:10.2217/FNL.14.33

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Author Alomair, Othman I.
Smith, Maree T.
Brereton, Ian M.
Galloway, Graham J.
Kurniawan, Nyoman D.
Title Current developments in MRI for assessing rodent models of multiple sclerosis
Journal name Future Neurology   Check publisher's open access policy
ISSN 1479-6708
1748-6971
Publication date 2014-01-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.2217/FNL.14.33
Open Access Status File (Author Post-print)
Volume 9
Issue 4
Start page 487
End page 511
Total pages 25
Place of publication London, United Kingdom
Publisher Future Medicine
Collection year 2015
Language eng
Abstract MRI is a key radiological imaging technique that plays an important role in the diagnosis and characterization of heterogeneous multiple sclerosis (MS) lesions. Various MRI methodologies such as conventional T 1/T 2 contrast, contrast agent enhancement, diffusion-weighted imaging, magnetization transfer imaging and susceptibility weighted imaging have been developed to determine the severity of MS pathology, including demyelination/remyelination and brain connectivity impairment from axonal loss. The broad spectrum of MS pathology manifests in diverse patient MRI presentations and affects the accuracy of patient diagnosis. To study specific pathological aspects of the disease, rodent models such as experimental autoimmune encephalomyelitis, virus-induced and toxin-induced demyelination have been developed. This review aims to present key developments in MRI methodology for better characterization of rodent models of MS.
Keyword Axonal loss
Demyelination
Diffusion-weighted imaging
Experimental autoimmune encephalomyelitis
Inflammation
Magnetic resonance imaging
Magnetization transfer imaging
Multiple sclerosis
Rodent model of multiple sclerosis
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2015 Collection
School of Pharmacy Publications
Centre for Advanced Imaging Publications
 
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Created: Fri, 29 Aug 2014, 22:05:54 EST by Shona Osborne on behalf of Centre for Advanced Imaging