Evaluation of polycaprolactone matrices for the intravaginal delivery of metronidazole in the treatment of bacterial vaginosis

Pathak, Meenakshi, Turner, Mark, Palmer, Cheryn and Coombes, Allan G. A. (2014) Evaluation of polycaprolactone matrices for the intravaginal delivery of metronidazole in the treatment of bacterial vaginosis. Journal of Biomaterials Applications, 29 3: 354-363. doi:10.1177/0885328214528256

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Author Pathak, Meenakshi
Turner, Mark
Palmer, Cheryn
Coombes, Allan G. A.
Title Evaluation of polycaprolactone matrices for the intravaginal delivery of metronidazole in the treatment of bacterial vaginosis
Journal name Journal of Biomaterials Applications   Check publisher's open access policy
ISSN 0885-3282
1530-8022
Publication date 2014-01-01
Year available 2014
Sub-type Article (original research)
DOI 10.1177/0885328214528256
Open Access Status File (Author Post-print)
Volume 29
Issue 3
Start page 354
End page 363
Total pages 10
Place of publication London, United Kingdom
Publisher Sage Publications Ltd.
Collection year 2015
Language eng
Formatted abstract
Microporous, poly (ε-caprolactone) (PCL) matrices loaded with the antibacterial, metronidazole were produced by rapidly cooling suspensions of drug powder in PCL solutions in acetone. Drug incorporation in the matrices increased from 2.0% to 10.6% w/w on raising the drug loading of the PCL solution from 5% to 20% w/w measured with respect to the PCL content. Drug loading efficiencies of 40-53% were obtained. Rapid 'burst release' of 35-55% of the metronidazole content was recorded over 24 h when matrices were immersed in simulated vaginal fluid (SVF), due to the presence of large amounts of drug on matrix surface as revealed by Raman microscopy. Gradual release of around 80% of the drug content occurred over the following 12 days. Metronidazole released from PCL matrices in SVF retained antimicrobial activity against Gardnerella vaginalis in vitro at levels up to 97% compared to the free drug. Basic modelling predicted that the concentrations of metronidazole released into vaginal fluid in vivo from a PCL matrix in the form of an intravaginal ring would exceed the minimum inhibitory concentration of metronidazole against G. vaginalis. These findings recommend further investigation of PCL matrices as intravaginal devices for controlled delivery of metronidazole in the treatment and prevention of bacterial vaginosis
Keyword Bacterial Vaginosis
Intravaginal rings
Metronidazole
Polycaprolactone
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: School of Agriculture and Food Sciences
Official 2015 Collection
School of Pharmacy Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 2 times in Thomson Reuters Web of Science Article | Citations
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Created: Tue, 26 Aug 2014, 22:38:49 EST by Charna Kovacevic on behalf of School of Pharmacy