New paradigms in the histopathology of NAFLD

Clouston, Andrew D., Gadd, Victoria L., Irvine, Katharine M. and Powell, Elizabeth E. (2014) New paradigms in the histopathology of NAFLD. Current Hepatitis Reports, 13 2: 81-87. doi:10.1007/s11901-014-0214-x

Author Clouston, Andrew D.
Gadd, Victoria L.
Irvine, Katharine M.
Powell, Elizabeth E.
Title New paradigms in the histopathology of NAFLD
Journal name Current Hepatitis Reports   Check publisher's open access policy
ISSN 1541-0706
Publication date 2014
Year available 2014
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1007/s11901-014-0214-x
Open Access Status
Volume 13
Issue 2
Start page 81
End page 87
Total pages 7
Place of publication Philadelphia, PA United States
Publisher Springer Healthcare
Collection year 2015
Language eng
Subject 2721 Hepatology
2406 Virology
Abstract Non-alcoholic fatty liver disease (NAFLD) is a rapidly growing global health problem. It can be separated histologically into two broad groups: steatosis, which usually follows a benign clinical course and non-alcoholic steatohepatitis (NASH) that typically has hepatocyte ballooning, necroinflammatory activity and can progress to fibrosis and cirrhosis. More recently the histological spectrum has expanded with the recognition of a paediatric pattern of NASH that has portal-based inflammation and fibrosis without ballooning. An overlap pattern is also described. There is increasing interest in the portal changes of NASH as these correlate with the progression of fibrosis. Disease-associated hepatocyte senescence appears to trigger an alternative regenerative pathway and the development of a periportal ductular reaction (DR), which in turn may have a role in progressive fibrogenesis. Portal inflammation, particularly in association with the DR, is an area of recent study.
Keyword Ballooning
Ductular reaction
Hepatic progenitor cell
Non alcoholic steatohepatitis
Paediatric liver disease
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2015 Collection
School of Medicine Publications
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