The Australian Register of Antiepileptic Drugs in Pregnancy: Changes over time in the epileptic population

Vajda, F. J. E., O'Brien, T. J., Graham, J., Lander, C. M. and Eadie, M. J. (2014) The Australian Register of Antiepileptic Drugs in Pregnancy: Changes over time in the epileptic population. Journal of Clinical Neuroscience, 21 9: 1478-1482. doi:10.1016/j.jocn.2013.11.049


Author Vajda, F. J. E.
O'Brien, T. J.
Graham, J.
Lander, C. M.
Eadie, M. J.
Title The Australian Register of Antiepileptic Drugs in Pregnancy: Changes over time in the epileptic population
Journal name Journal of Clinical Neuroscience   Check publisher's open access policy
ISSN 0967-5868
1532-2653
Publication date 2014
Year available 2014
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.jocn.2013.11.049
Open Access Status
Volume 21
Issue 9
Start page 1478
End page 1482
Total pages 5
Place of publication London, United Kingdom
Publisher Churchill Livingstone
Collection year 2015
Language eng
Abstract The demographic characteristics, details of pregnancies, epilepsies, and treatment of 855 pregnant women with epilepsy enrolled in the Australian Antiepileptic Drugs in Pregnancy Register during 1999-2005 were compared with the corresponding data for the 801 women enrolled from 2006-2012. We estimate that the Register captures approximately 1 in 12 of all pregnancies in Australian women with epilepsy. A number of statistically significant changes were found, with nearly all explained by factors such as re-enrolment of women who had enrolled earlier pregnancies, changes in general population behaviour, altered attitudes to prescribing valproate and using it in lower doses, and the advent of newer antiepileptic drugs which have displaced the use of older agents. It appears that the Register has continued to capture a reasonably representative sample of pregnant Australian women with epilepsy as time has passed.
Keyword Antiepileptic drugs
Demography
Pregnancy register
Valproate
Women with epilepsy
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2015 Collection
School of Medicine Publications
 
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