Breast cancer risk, nightwork, and circadian clock gene polymorphisms

Truong, Therese, Liquet, Benoit, Menegaux, Florence, Plancoulaine, Sabine, Laurent-Puig, Pierre, Mulot, Claire, Cordina-Duverger, Emilie, Sanchez, Marie, Arveux, Patrick, Kerbrat, Pierre, Richardson, Sylvia and Guenel, Pascal (2014) Breast cancer risk, nightwork, and circadian clock gene polymorphisms. Endocrine-Related Cancer, 21 4: 629-638. doi:10.1530/ERC-14-0121


Author Truong, Therese
Liquet, Benoit
Menegaux, Florence
Plancoulaine, Sabine
Laurent-Puig, Pierre
Mulot, Claire
Cordina-Duverger, Emilie
Sanchez, Marie
Arveux, Patrick
Kerbrat, Pierre
Richardson, Sylvia
Guenel, Pascal
Title Breast cancer risk, nightwork, and circadian clock gene polymorphisms
Journal name Endocrine-Related Cancer   Check publisher's open access policy
ISSN 1479-6821
1351-0088
Publication date 2014-08-01
Year available 2014
Sub-type Article (original research)
DOI 10.1530/ERC-14-0121
Open Access Status DOI
Volume 21
Issue 4
Start page 629
End page 638
Total pages 10
Place of publication Woodlands, Bristol, United Kingdom
Publisher BioScientifica
Collection year 2015
Language eng
Abstract Night shiftwork has been associated with an increased risk of breast cancer pointing to a role of circadian disruption. We investigated the role of circadian clock gene polymorphisms and their interaction with nightwork in breast cancer risk in a population-based case - control study in France including 1126 breast cancer cases and 1174 controls. We estimated breast cancer risk associated with each of the 577 single nucleotide polymorphisms (SNPs) in 23 circadian clock genes. We also used a gene- and pathway-based approach to investigate the overall effect on breast cancer of circadian clock gene variants that might not be detected in analyses based on individual SNPs. Interactions with nightwork were tested at the SNP, gene, and pathway levels. We found that two SNPs in RORA (rs1482057 and rs12914272) were associated with breast cancer in the whole sample and among postmenopausal women. In this subpopulation, we also reported an association with rs11932595 in CLOCK, and with CLOCK, RORA, and NPAS2 in the analyses at thegenelevel. Breast cancer risk in postmenopausal women was also associated with overall genetic variation in the circadian gene pathway (P=0.04), but this association was not detected in premenopausal women. There was some evidence of an interaction between PER1 and nightwork in breast cancer in the whole sample (P=0.024), although the effect was not statistically significant after correcting for multiple testing (P=0.452). Our results support the hypothesis that circadian clock gene variants modulate breast cancer risk.
Keyword Breast cancer
Case-control study
Circadian rhythm
Nightwork
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: School of Mathematics and Physics
Official 2015 Collection
 
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