Waning vaccine immunity in teenagers primed with whole cell and acellular pertussis vaccine: recent epidemiology

Sheridan, Sarah L., Frith, Katie, Snelling, Thomas L., Grimwood, Keith, McIntyre, Peter B. and Lambert, Stephen B. (2014) Waning vaccine immunity in teenagers primed with whole cell and acellular pertussis vaccine: recent epidemiology. Expert Review of Vaccines, 13 9: 1081-1106. doi:10.1586/14760584.2014.944167


Author Sheridan, Sarah L.
Frith, Katie
Snelling, Thomas L.
Grimwood, Keith
McIntyre, Peter B.
Lambert, Stephen B.
Title Waning vaccine immunity in teenagers primed with whole cell and acellular pertussis vaccine: recent epidemiology
Journal name Expert Review of Vaccines   Check publisher's open access policy
ISSN 1744-8395
1476-0584
Publication date 2014-09
Year available 2014
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1586/14760584.2014.944167
Open Access Status
Volume 13
Issue 9
Start page 1081
End page 1106
Total pages 26
Place of publication London, United Kingdom
Publisher Expert Reviews
Collection year 2015
Language eng
Abstract The recent epidemics of pertussis (whooping cough) in parts of the USA and Australia have led to the largest numbers of annual cases reported in over half a century. These epidemics demonstrated a new pattern, with particularly high rates of disease among pre-adolescents and early adolescents. These high rates of pertussis coincided with the first cohorts vaccinated with purely acellular pertussis vaccine, which replaced whole-cell pertussis (wP) vaccine in the later 1990s in the USA and Australia. Studies undertaken during these epidemics provide new evidence of more rapid waning of acellular pertussis-containing vaccines and longer-term protection from effective wP-containing vaccines. There is evidence that receiving wP as at least the first dose of pertussis-containing vaccine provides greater and more long-lived protection, irrespective of the nature of subsequent doses. This evidence will be reviewed together with the immunobiology associated with both vaccines, and the implications for pertussis control discussed.
Keyword Acellular pertussis vaccine
Pertussis immunobiology
Teenagers
Vaccine effectiveness
Vaccine efficacy
Waning protection
Whole-cell pertussis vaccine
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2015 Collection
Queensland Children's Medical Research Institute Publications
Faculty of Medicine
School of Public Health Publications
 
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