PEG-based hyperbranched polymer theranostics: optimizing chemistries for improved bioconjugation

Ardana, Aditya, Whittaker, Andrew K. and Thurecht, Kristofer J. (2014) PEG-based hyperbranched polymer theranostics: optimizing chemistries for improved bioconjugation. Macromolecules, 47 15: 5211-5219. doi:10.1021/ma501196h

Author Ardana, Aditya
Whittaker, Andrew K.
Thurecht, Kristofer J.
Title PEG-based hyperbranched polymer theranostics: optimizing chemistries for improved bioconjugation
Journal name Macromolecules   Check publisher's open access policy
ISSN 1520-5835
Publication date 2014-08-12
Year available 2014
Sub-type Article (original research)
DOI 10.1021/ma501196h
Open Access Status
Volume 47
Issue 15
Start page 5211
End page 5219
Total pages 9
Place of publication Washington, DC, United States
Publisher American Chemical Society
Collection year 2015
Formatted abstract
Polymeric materials are receiving increasing attention as gene delivery vectors in nanomedicine. Because of their potential to combine many different functionalities into a single molecule, hyperbranched polymers (HBPs) are ideal for biomedical applications and have been utilized in a variety of applications ranging from molecular imaging to vectors for gene and drug delivery. In this study, we synthesized a model functional HBP as a potential theranostic, which can act as an imaging agent for 19F MRI while at the same time carrying specific therapeutic genes (such as small-interfering RNA) to a site of interest. In order to realize such a goal, an in-depth analysis of the molecular structure of the theranostic was performed to ensure that the diagnostic (19F MRI) and therapeutic (gene therapy) components were complementary and did not compromise respective individual function. Importantly, it was necessary to demonstrate that the various chemistries utilized during the synthesis of the theranostic HBPs were compatible and did not lead to unwanted degradation and subsequent formation of side-products. Ultimately, we show that through careful analysis of the polymeric materials we can gain an understanding of the subtle factors that influence successful development of a theranostic device that incorporates multiple specific functionalities.
Keyword F-19 magnetic resonance
MRI contrast agents
Raft polymerisation
siRNA delivery
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
Australian Institute for Bioengineering and Nanotechnology Publications
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Citation counts: TR Web of Science Citation Count  Cited 8 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 7 times in Scopus Article | Citations
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