Impact of Impaired Maternal Vitamin A Status on Infant Eyes

Coman, David and Gole, Glen (2014). Impact of Impaired Maternal Vitamin A Status on Infant Eyes. In Victor R. Preedy (Ed.), Handbook of nutrition, diet and the eye (pp. 377-382) Burlington, MA United States: Elsevier Science. doi:10.1016/B978-0-12-401717-7.00038-1


Author Coman, David
Gole, Glen
Title of chapter Impact of Impaired Maternal Vitamin A Status on Infant Eyes
Title of book Handbook of nutrition, diet and the eye
Place of Publication Burlington, MA United States
Publisher Elsevier Science
Publication Year 2014
Sub-type Research book chapter (original research)
DOI 10.1016/B978-0-12-401717-7.00038-1
Year available 2014
ISBN 9780124017177
9780124046061
Editor Victor R. Preedy
Chapter number 38
Start page 377
End page 382
Total pages 6
Total chapters 65
Collection year 2015
Language eng
Formatted Abstract/Summary
Fetal and neonatal vitamin A deficiency exhibits protean clinical manifestations, which reflect the importance of vitamin A in cell cycle fate, embryogenesis, and organogenesis. The metabolism and nuclear signaling roles of vitamin A derivatives are still to be fully elucidated. Key ophthalmologic manifestations of neonatal vitamin A deficiency include microcornea, Bitot spots, xerophthalmia, and anterior and posterior segment malformations. Historically, maternal hypovitaminosis A secondary to nutritional deficiencies has been prevalent in the developing world; however, maternal hypovitaminosis A and consequent neonatal malformation syndromes are being reported with increasing frequency following gastric bypass surgery for maternal morbid obesity. This chapter discusses vitamin A metabolism, clinical multisystem malformation syndromes associated with perturbations of vitamin A homeostasis and biosynthesis, and the role of vitamin A in ocular development.
Keyword Retinoic Acid
Biliopancreatic Diversion
Stra6 Mutations
Morbid obesity
Deficiency
Anophthalmia
Q-Index Code BX
Q-Index Status Confirmed Code
Institutional Status UQ

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