Nocturnal oxygen saturation profiles of healthy term infants

Terrill, Philip, Dakin, Carolyn, Hughes, Ian and Parsley, Chloe (2014) Nocturnal oxygen saturation profiles of healthy term infants. Archives of Disease in Childhood, 100 1: 18-23. doi:10.1136/archdischild-2013-305708

Author Terrill, Philip
Dakin, Carolyn
Hughes, Ian
Parsley, Chloe
Title Nocturnal oxygen saturation profiles of healthy term infants
Journal name Archives of Disease in Childhood   Check publisher's open access policy
ISSN 0003-9888
Publication date 2014-07-25
Year available 2014
Sub-type Article (original research)
DOI 10.1136/archdischild-2013-305708
Open Access Status
Volume 100
Issue 1
Start page 18
End page 23
Total pages 6
Place of publication London, United Kingdom
Publisher B M J Group
Collection year 2015
Language eng
Formatted abstract
Objective Pulse oximetry is used extensively in hospital and home settings to measure arterial oxygen saturation (SpO2). Interpretation of the trend and range of SpO2 values observed in infants is currently limited by a lack of reference ranges using current devices, and may be augmented by development of cumulative frequency (CF) reference-curves. This study aims to provide reference oxygen saturation values from a prospective longitudinal cohort of healthy infants. Design Prospective longitudinal cohort study. Setting Sleep-laboratory. Patients 34 healthy term infants were enrolled, and studied at 2 weeks, 3, 6, 12 and 24 months of age (N=30, 25, 27, 26, 20, respectively). Interventions Full overnight polysomnography, including 2 s averaging pulse oximetry (Masimo Radical). Main outcome measurements Summary SpO2 statistics (mean, median, 5th and 10th percentiles) and SpO2 CF plots were calculated for each recording. CF reference-curves were then generated for each study age. Analyses were repeated with sleep-state stratifications and inclusion of manual artefact removal. Results Median nocturnal SpO2 values ranged between 98% and 99% over the first 2 years of life and the CF reference-curves shift right by 1% between 2 weeks and 3 months. CF reference-curves did not change with manual artefact removal during sleep and did not vary between rapid eye movement (REM) and non-REM sleep. Manual artefact removal did significantly change summary statistics and CF reference-curves during wake. Conclusions SpO2 CF curves provide an intuitive visual tool for evaluating whether an individual's nocturnal SpO2 distribution falls within the range of healthy age-matched infants, thereby complementing summary statistics in the interpretation of extended oximetry recordings in infants.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Information Technology and Electrical Engineering Publications
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Created: Wed, 20 Aug 2014, 10:45:26 EST by Dr Philip Terrill on behalf of School of Information Technol and Elec Engineering