Post-partum anoestrus in tropical beef cattle: a systems approach combining gene expression and genome-wide association results

Fortes, Marina R. S., Suhaimi, Ainu H. M. S., Porto-Neto, Laercio R., McWilliam, Sean M., Flatscher-Bader, Trudi, Moore, Stephen S., D'Occhio, Michael J., Meira, Camila T., Thomas, Milton G., Snelling, Warren M., Reverter, Antonio and Lehnert, Sigrid A. (2014) Post-partum anoestrus in tropical beef cattle: a systems approach combining gene expression and genome-wide association results. Livestock Science, 166 158-166. doi:10.1016/j.livsci.2014.06.017

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads
UQ337401_OA.pdf Full text (open access) application/pdf 731.48KB 4

Author Fortes, Marina R. S.
Suhaimi, Ainu H. M. S.
Porto-Neto, Laercio R.
McWilliam, Sean M.
Flatscher-Bader, Trudi
Moore, Stephen S.
D'Occhio, Michael J.
Meira, Camila T.
Thomas, Milton G.
Snelling, Warren M.
Reverter, Antonio
Lehnert, Sigrid A.
Title Post-partum anoestrus in tropical beef cattle: a systems approach combining gene expression and genome-wide association results
Journal name Livestock Science   Check publisher's open access policy
ISSN 1871-1413
Publication date 2014-08
Year available 2014
Sub-type Article (original research)
DOI 10.1016/j.livsci.2014.06.017
Open Access Status
Volume 166
Start page 158
End page 166
Total pages 9
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Collection year 2015
Language eng
Abstract The length of the post-partum anoestrous interval affects reproductive efficiency in many tropical beef cattle herds. In this study, results from genome-wide association studies (Experiment 1: GWAS) and gene expression (Experiment 2: microarray) were combined in a systems approach to reveal genetic markers, genes and pathways underlying the physiology of post-partum anoestrus in tropically adapted cattle. The microarray study measured the expression of 13,964 genes in the hypothalamus of Brahman cows. A total of 366 genes were differentially expressed (DE) in the post-partum period, when acyclic cows were compared to cows that had resumed ovarian cycles. Associated markers (P<0.05) from a high density GWAS pointed to 2829 genes that were associated with post-partum anoestrous interval (PPAI) in two populations of beef cattle: Brahman and Tropical composite. Together the experiments provided evidence for 63 genes that are likely to influence the resumption of ovulation post-partum in tropically adapted beef cattle. Functional annotation analysis revealed that some of the 63 genes have known roles in hormonal activity, energy balance and neuronal synapse plasticity. Polymorphisms within candidate genes identified by this systems approach could have biological significance in post-partum anoestrus and help select Zebu (Bos indicus) influenced cattle with genetic potential for shorter post-partum anoestrus.
Keyword Zebu
Hypothalamus
Genomics
Microarray
Anoestrus
Fertility
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Alliance for Agriculture and Food Innovation
Official 2015 Collection
School of Chemistry and Molecular Biosciences
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 2 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 2 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 19 Aug 2014, 04:19:00 EST by System User on behalf of Centre for Animal Science