P-glycoprotein and its role in drug-drug interactions

Finch, Andrew and Pillans, Peter (2014) P-glycoprotein and its role in drug-drug interactions. Australian Prescriber, 37 4: 137-139.

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Author Finch, Andrew
Pillans, Peter
Title P-glycoprotein and its role in drug-drug interactions
Journal name Australian Prescriber   Check publisher's open access policy
ISSN 0312-8008
1839-3942
Publication date 2014
Year available 2014
Sub-type Article (original research)
Open Access Status File (Publisher version)
Volume 37
Issue 4
Start page 137
End page 139
Total pages 3
Place of publication Deakin, ACT Australia
Publisher Australian Government Publishing Service
Collection year 2015
Language eng
Formatted abstract
Efflux transporters such as P-glycoprotein play an important role in drug transport in many organs. In the gut, P-glycoprotein pumps drugs back into the lumen, decreasing their absorption.  

Drugs which induce P-glycoprotein, such as rifampicin, can reduce the bioavailability of some other drugs. Inhibitors of P-glycoprotein, such as verapamil, increase the bioavailability of susceptible drugs.

Many, but not all, of the drugs which are transported by P-glycoprotein are also metabolised by cytochrome P450 3A4.

Important substrates of P-glycoprotein include calcium channel blockers, cyclosporin, dabigatran etexilate, digoxin, erythromycin, loperamide, protease inhibitors and tacrolimus. Predicting clinically important interactions is difficult because of interindividual differences in drug transport.
Keyword Digoxin
Pharmacokinetics
Q-Index Code CX
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
Official Audit
School of Medicine Publications
 
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Created: Tue, 19 Aug 2014, 03:01:58 EST by System User on behalf of School of Medicine