P-glycoprotein and its role in drug-drug interactions

Finch, Andrew and Pillans, Peter (2014) P-glycoprotein and its role in drug-drug interactions. Australian Prescriber, 37 4: 137-139.

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads
UQ337365_OA.pdf Full text (open access) application/pdf 122.13KB 69
Author Finch, Andrew
Pillans, Peter
Title P-glycoprotein and its role in drug-drug interactions
Journal name Australian Prescriber   Check publisher's open access policy
ISSN 0312-8008
Publication date 2014
Year available 2014
Sub-type Article (original research)
Open Access Status File (Publisher version)
Volume 37
Issue 4
Start page 137
End page 139
Total pages 3
Place of publication Deakin, ACT Australia
Publisher Australian Government Publishing Service
Collection year 2015
Language eng
Formatted abstract
Efflux transporters such as P-glycoprotein play an important role in drug transport in many organs. In the gut, P-glycoprotein pumps drugs back into the lumen, decreasing their absorption.  

Drugs which induce P-glycoprotein, such as rifampicin, can reduce the bioavailability of some other drugs. Inhibitors of P-glycoprotein, such as verapamil, increase the bioavailability of susceptible drugs.

Many, but not all, of the drugs which are transported by P-glycoprotein are also metabolised by cytochrome P450 3A4.

Important substrates of P-glycoprotein include calcium channel blockers, cyclosporin, dabigatran etexilate, digoxin, erythromycin, loperamide, protease inhibitors and tacrolimus. Predicting clinically important interactions is difficult because of interindividual differences in drug transport.
Keyword Digoxin
Q-Index Code CX
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
Official Audit
School of Medicine Publications
Version Filter Type
Citation counts: Scopus Citation Count Cited 0 times in Scopus Article
Google Scholar Search Google Scholar
Created: Tue, 19 Aug 2014, 03:01:58 EST by System User on behalf of School of Medicine