In vitro pre-vascularisation of tissue-engineered constructs A co-culture perspective

Baldwin, Jeremy, Antille, Mélanie, Bonda, Ulrich, De-Juan-Pardo, Elena M., Khosrotehrani, Kiarash, Ivanovski, Saso, Petcu, Eugen Bogdan and Hutmacher, Dietmar Werner (2014) In vitro pre-vascularisation of tissue-engineered constructs A co-culture perspective. Vascular Cell, 6 1: 13.1-13.16. doi:10.1186/2045-824X-6-13


Author Baldwin, Jeremy
Antille, Mélanie
Bonda, Ulrich
De-Juan-Pardo, Elena M.
Khosrotehrani, Kiarash
Ivanovski, Saso
Petcu, Eugen Bogdan
Hutmacher, Dietmar Werner
Title In vitro pre-vascularisation of tissue-engineered constructs A co-culture perspective
Formatted title
In vitro pre-vascularisation of tissue-engineered constructs A co-culture perspective
Journal name Vascular Cell   Check publisher's open access policy
ISSN 2045-824X
Publication date 2014-06-21
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1186/2045-824X-6-13
Open Access Status DOI
Volume 6
Issue 1
Start page 13.1
End page 13.16
Total pages 16
Place of publication London, United Kingdom
Publisher BioMed Central
Collection year 2015
Abstract In vitro pre-vascularization is one of the main vascularization strategies in the tissue engineering field. Culturing cells within a tissue-engineered construct (TEC) prior to implantation provides researchers with a greater degree of control over the fate of the cells. However, balancing the diverse range of different cell culture parameters in vitro is seldom easy and in most cases, especially in highly vascularized tissues, more than one cell type will reside within the cell culture system. Culturing multiple cell types in the same construct presents its own unique challenges and pitfalls. The following review examines endothelial-driven vascularization and evaluates the direct and indirect role other cell types have in vessel and capillary formation. The article then analyses the different parameters researchers can modulate in a co-culture system in order to design optimal tissue-engineered constructs to match desired clinical applications.
Keyword Co-culture
Matrices
Tissue engineering
Vascularisation
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: UQ Centre for Clinical Research Publications
Official 2015 Collection
School of Medicine Publications
UQ Diamantina Institute Publications
 
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