Daily use of sildenafil improves endothelial function in men with type 2 diabetes

Deyoung, Ling, Chung, Eric, Kovac, Jason R., Romano, Walter and Brock, Gerald B. (2012) Daily use of sildenafil improves endothelial function in men with type 2 diabetes. Journal of Andrology, 33 2: 176-180. doi:10.2164/jandrol.111.013367

Author Deyoung, Ling
Chung, Eric
Kovac, Jason R.
Romano, Walter
Brock, Gerald B.
Title Daily use of sildenafil improves endothelial function in men with type 2 diabetes
Journal name Journal of Andrology   Check publisher's open access policy
ISSN 0196-3635
Publication date 2012
Sub-type Article (original research)
DOI 10.2164/jandrol.111.013367
Open Access Status
Volume 33
Issue 2
Start page 176
End page 180
Total pages 5
Place of publication Schaumburg, IL, United States
Publisher American Society of Andrology
Language eng
Abstract Diminished vascular endothelial function results in decreased vasodilator capacity and is associated with erectile dysfunction (ED) in patients afflicted with type 2 diabetes. The current study was designed to evaluate whether daily use of sildenafil could alter endothelial function and improve penile rigidity in a group of patients with diabetic ED. A double-blind, placebo-controlled, prospective trial was conducted with 24 men with type 2 diabetes who were randomized into 2 groups: one receiving daily sildenafil (50 mg, n = 12) and the other placebo (n = 12) for 10 weeks. Erectile function was captured subjectively using the International Index of Erectile Function (IIEF-5), and endothelial function was objectively monitored via brachial artery flow-mediated dilation. Among the placebo and sildenafil groups, there were no significant differences in average patient age, time from type 2 diabetes diagnosis, duration of ED, or baseline IIEF-5 scores. Past medical histories, including smoking, alcohol consumption, hypertension, and hyperlipidemia, were also similar. At the conclusion of the 10-week trial, patients who received daily sildenafil had significantly improved erectile rigidity as captured by IIEF-5 (P <.001) and increased endothelial function via brachial artery flow-mediated dilation (P <.01). Endothelial function in men with type 2 diabetes was enhanced with daily sildenafil. Improved erectile rigidity and enhanced vascular circulation was noted after 10 weeks of daily sildenafil use.
Keyword Erectile dysfunction
Flow mediated dilation
Nitric oxide
PDE5 inhibition
Penile rigidity
Randomized control trial
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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