A Staphylococcus aureus Regulatory System that Responds to Host Heme and Modulates Virulence

Torres V.J., Stauff D.L., Pishchany G., Bezbradica J.S., Gordy L.E., Iturregui J., Anderson KelsiL., Dunman P.M., Joyce S. and Skaar E.P. (2007) A Staphylococcus aureus Regulatory System that Responds to Host Heme and Modulates Virulence. Cell Host and Microbe, 1 2: 109-119. doi:10.1016/j.chom.2007.03.001


Author Torres V.J.
Stauff D.L.
Pishchany G.
Bezbradica J.S.
Gordy L.E.
Iturregui J.
Anderson KelsiL.
Dunman P.M.
Joyce S.
Skaar E.P.
Title A Staphylococcus aureus Regulatory System that Responds to Host Heme and Modulates Virulence
Journal name Cell Host and Microbe   Check publisher's open access policy
ISSN 1931-3128
Publication date 2007-04-19
Sub-type Article (original research)
DOI 10.1016/j.chom.2007.03.001
Volume 1
Issue 2
Start page 109
End page 119
Total pages 11
Language eng
Subject 2400 Immunology and Microbiology
1306 Cancer Research
1312 Molecular Biology
Abstract Staphylococcus aureus, a bacterium responsible for tremendous morbidity and mortality, exists as a harmless commensal in approximately 25% of humans. Identifying the molecular machinery activated upon infection is central to understanding staphylococcal pathogenesis. We describe the heme sensor system (HssRS) that responds to heme exposure and activates expression of the heme-regulated transporter (HrtAB). Inactivation of the Hss or Hrt systems leads to increased virulence in a vertebrate infection model, a phenotype that is associated with an inhibited innate immune response. We suggest that the coordinated activity of Hss and Hrt allows S. aureus to sense internal host tissues, resulting in tempered virulence to avoid excessive host tissue damage. Further, genomic analyses have identified orthologous Hss and Hrt systems in Bacillus anthracis, Listeria monocytogenes, and Enterococcus faecalis, suggesting a conserved regulatory system by which Gram-positive pathogens sense heme as a molecular marker of internal host tissue and modulate virulence.
Keyword MICROBIO
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
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Citation counts: TR Web of Science Citation Count  Cited 101 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 97 times in Scopus Article | Citations
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