Integration of cytokine and heterologous receptor signaling pathways

Bezbradica, Jelena S. and Medzhitov, Ruslan (2009) Integration of cytokine and heterologous receptor signaling pathways. Nature Immunology, 10 4: 333-339. doi:10.1038/ni.1713


Author Bezbradica, Jelena S.
Medzhitov, Ruslan
Title Integration of cytokine and heterologous receptor signaling pathways
Journal name Nature Immunology   Check publisher's open access policy
ISSN 1529-2908
1529-2916
Publication date 2009
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1038/ni.1713
Open Access Status
Volume 10
Issue 4
Start page 333
End page 339
Total pages 7
Place of publication New York, NY, United States
Publisher Nature
Language eng
Abstract Cytokines are soluble mediators of cell communication that are critical in immune regulation. They induce specific gene-expression programs in responsive cells. Recent findings, however, indicate that cytokine receptors can regulate immune cell functions by transcription-independent mechanisms. Here we review the current understanding of how cytokine signaling regulates the functions of other signaling pathways by first discussing the 'traditional' transcription-mediated consequences of cytokine signaling and then providing a detailed description of transcription-independent lateral communications between cytokine receptors and other cellular receptors.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: Institute for Molecular Bioscience - Publications
 
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