Role of ITAM signaling module in signal integration

Bezbradica, Jelena S. and Medzhitov, Ruslan (2012) Role of ITAM signaling module in signal integration. Current Opinion in Immunology, 24 1: 58-66. doi:10.1016/j.coi.2011.12.010


Author Bezbradica, Jelena S.
Medzhitov, Ruslan
Title Role of ITAM signaling module in signal integration
Journal name Current Opinion in Immunology   Check publisher's open access policy
ISSN 0952-7915
1879-0372
Publication date 2012
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.coi.2011.12.010
Open Access Status
Volume 24
Issue 1
Start page 58
End page 66
Total pages 9
Place of publication Kidlington, Oxford, United Kingdom
Publisher Elsevier
Language eng
Abstract Diverse cell types use a small number of evolutionarily conserved signaling modules to integrate external cues and elicit distinct functions. A question thus arises as to how does a receptor, which contains a single signaling module, produce distinct outcomes to diverse signals, particularly if such module is shared amongst a family of receptors? Emerging data suggest that many immunoreceptors, all of which use a conserved ITAM-module for their signaling, can couple with members of additional classes of membrane receptors to deliver unique signal(s) to the cell. We discuss the possible biological purposes and mechanisms behind these interactions at the plasma membrane. We offer a conceptual framework to understand information processing within the immune system and discuss the new biology of old receptors involving their structural and functional collaborations that evolved to deliver unique signal(s) to the cell using a limited set of conserved signaling modules.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: Institute for Molecular Bioscience - Publications
 
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