Granulocyte-Macrophage Colony-Stimulating Factor Regulates Effector Differentiation of Invariant Natural Killer T Cells during Thymic Ontogeny

Bezbradica J.S., Gordy L.E., Stanic A.K., Dragovic S., Hill T., Hawiger J., Unutmaz D., Van Kaer L. and Joyce S. (2006) Granulocyte-Macrophage Colony-Stimulating Factor Regulates Effector Differentiation of Invariant Natural Killer T Cells during Thymic Ontogeny. Immunity, 25 3: 487-497. doi:10.1016/j.immuni.2006.06.017


Author Bezbradica J.S.
Gordy L.E.
Stanic A.K.
Dragovic S.
Hill T.
Hawiger J.
Unutmaz D.
Van Kaer L.
Joyce S.
Title Granulocyte-Macrophage Colony-Stimulating Factor Regulates Effector Differentiation of Invariant Natural Killer T Cells during Thymic Ontogeny
Journal name Immunity   Check publisher's open access policy
ISSN 1074-7613
Publication date 2006
Sub-type Article (original research)
DOI 10.1016/j.immuni.2006.06.017
Volume 25
Issue 3
Start page 487
End page 497
Total pages 11
Language eng
Subject 2723 Immunology and Allergy
2725 Infectious Diseases
2403 Immunology
Abstract Invariant natural killer T (iNKT) cell-derived cytokines have important functions in inflammation, host defense, and immunoregulation. Yet, when and how iNKT cells undergo effector differentiation, which endows them with the capacity to rapidly secrete cytokines upon activation, remains unknown. We discovered that granulocyte-macrophage colony-stimulating factor (Csf-2)-deficient mice developed iNKT cells that failed to respond to the model antigen α-galactosylceramide because of an intrinsic defect in the fusion of secretory vesicles with the plasma membrane. Exogenous Csf-2 corrected the functional defect only when supplied during the development of thymic, but not mature, splenic Csf-2-deficient iNKT cells. Thus, we ascribe a unique function to Csf-2, which regulates iNKT cell effector differentiation during development by a mechanism that renders them competent for cytokine secretion.
Keyword CELLIMMUNO
DEVBIO
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
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