Circulating gastrin is increased in hemochromatosis

Smith K.A., Kovac S., Anderson G.J., Shulkes A. and Baldwin G.S. (2006) Circulating gastrin is increased in hemochromatosis. FEBS Letters, 580 26: 6195-6198. doi:10.1016/j.febslet.2006.10.021

Author Smith K.A.
Kovac S.
Anderson G.J.
Shulkes A.
Baldwin G.S.
Title Circulating gastrin is increased in hemochromatosis
Journal name FEBS Letters   Check publisher's open access policy
ISSN 0014-5793
Publication date 2006-11-13
Sub-type Article (original research)
DOI 10.1016/j.febslet.2006.10.021
Volume 580
Issue 26
Start page 6195
End page 6198
Total pages 4
Language eng
Subject 1303 Specialist Studies in Education
1304 Biophysics
1312 Molecular Biology
Abstract Gastric acid production is important in intestinal iron absorption. The peptide hormone gastrin exists in both amidated and non-amidated forms, which stimulate and potentiate gastric acid secretion, respectively. Since non-amidated gastrins require ferric ions for biological activity in vitro, this study investigated the connection between iron status and gastrin by measurement of circulating gastrin concentrations in mice and humans with hemochromatosis. Gastrin concentrations are increased in the plasma and gastric mucosa of Hfe-/- mice, and in the sera of humans with HFE-related hemochromatosis. The discovery of a relationship between iron status and circulating gastrin concentrations opens a new perspective on the mechanisms of iron homeostasis.
Keyword Ferric
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
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