Rotation and asymmetric development of the zebrafish heart requires directed migration of cardiac progenitor cells

Smith, Kelly A., Chocron, Sonja, von der Hardt, Sophia, de Pater, Emma, Soufan, Alexander, Bussmann, Jeroen, Schulte-Merker, Stefan, Hammerschmidt, Matthias and Bakkers, Jeroen (2008) Rotation and asymmetric development of the zebrafish heart requires directed migration of cardiac progenitor cells. Developmental Cell, 14 2: 287-297. doi:10.1016/j.devcel.2007.11.015


Author Smith, Kelly A.
Chocron, Sonja
von der Hardt, Sophia
de Pater, Emma
Soufan, Alexander
Bussmann, Jeroen
Schulte-Merker, Stefan
Hammerschmidt, Matthias
Bakkers, Jeroen
Title Rotation and asymmetric development of the zebrafish heart requires directed migration of cardiac progenitor cells
Journal name Developmental Cell   Check publisher's open access policy
ISSN 1534-5807
1878-1551
Publication date 2008-02
Sub-type Article (original research)
DOI 10.1016/j.devcel.2007.11.015
Open Access Status
Volume 14
Issue 2
Start page 287
End page 297
Total pages 11
Place of publication Cambridge, United States
Publisher Cell Press
Language eng
Formatted abstract
We have used high-resolution 4D imaging of cardiac progenitor cells (CPCs) in zebrafish to investigate the earliest left-right asymmetric movements during cardiac morphogenesis. Differential migratory behavior within the heart field was observed, resulting in a rotation of the heart tube. The leftward displacement and rotation of the tube requires hyaluronan synthase 2 expression within the CPCs. Furthermore, by reducing or ectopically activating BMP signaling or by implantation of BMP beads we could demonstrate that BMP signaling, which is asymmetrically activated in the lateral plate mesoderm and regulated by early left-right signals, is required to direct CPC migration and cardiac rotation. Together, these results support a model in which CPCs migrate toward a BMP source during development of the linear heart tube, providing a mechanism by which the left-right axis drives asymmetric development of the vertebrate heart.
Keyword Dorsoventral pattern-formation
Gene-expression
Lateral cells
Chick-embryo
Morphogenesis
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Molecular Bioscience - Publications
 
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