An overview of recent patents on nanosuspension

Modh, Nirav, Mehta, Dharmik, Parejiya, Punit, Popat, Amirali and Barot, Bhavesh (2014) An overview of recent patents on nanosuspension. Recent Patents on Drug Delivery and Formulation, 8 2: 144-154. doi:10.2174/1872211308666140422150819

Author Modh, Nirav
Mehta, Dharmik
Parejiya, Punit
Popat, Amirali
Barot, Bhavesh
Title An overview of recent patents on nanosuspension
Journal name Recent Patents on Drug Delivery and Formulation   Check publisher's open access policy
ISSN 1872-2113
Publication date 2014
Year available 2014
Sub-type Critical review of research, literature review, critical commentary
DOI 10.2174/1872211308666140422150819
Open Access Status
Volume 8
Issue 2
Start page 144
End page 154
Total pages 11
Place of publication Bussum, The Netherlands
Publisher Bentham Science
Collection year 2015
Language eng
Subject 3003 Pharmaceutical Science
2204 Religion and Religious Studies
Abstract Pharmaceutical scientists involved in drug discovery and drug development are facing serious problems with newer poorly water soluble drugs with respect to their dissolution and bioavailability. Reducing the particle size of active pharmaceutical ingredient has been an efficient and reliable method for improving the bioavailability of insoluble drugs. Nanosuspension has emerged as an efficient and promising strategy for delivery of insoluble drugs due to its unique advantages such as ease of modification, process flexibility, targeting capabilities, altered pharmacokinetic profile leading to safety and efficacy. These unique features of nanosuspension have enabled its use in various dosage forms, including specialized delivery systems such as oral, parenteral, peroral, ocular and pulmonary routes. Currently, efforts are being directed to extend their applications in site-specific drug delivery. Large numbers of products based on nanosuspension are in the market and few are under clinical trials. The commercialization potential of nanosuspension based formulation for oral route is well established and products for other routes will enter the market within short span. Among the various techniques available, only wet milling technique has been successfully used for commercial production of nanosuspension. Nanosuspension based patents have extensive potential of reaching faster in the market as compared to other nanotechnology based formulations. This review covers various aspects of techniques of preparation, route of administration and commercialization of nanosuspension with main focus on the recent patents granted in the field.
Keyword Bioavailability
Drug delivery
Method of preparation
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
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