Association between feline immunodeficiency virus (FIV) plasma viral RNA load, concentration of acute phase proteins and disease severity

Kann, Rebecca K.C., Seddon, Jennifer M., Kyaw-Tanner, Myat T., Henning, Joerg and Meers, Joanne (2014) Association between feline immunodeficiency virus (FIV) plasma viral RNA load, concentration of acute phase proteins and disease severity. Veterinary Journal, 201 2: 181-183. doi:10.1016/j.tvjl.2014.01.023


Author Kann, Rebecca K.C.
Seddon, Jennifer M.
Kyaw-Tanner, Myat T.
Henning, Joerg
Meers, Joanne
Title Association between feline immunodeficiency virus (FIV) plasma viral RNA load, concentration of acute phase proteins and disease severity
Journal name Veterinary Journal   Check publisher's open access policy
ISSN 1532-2971
1090-0233
Publication date 2014-08-01
Year available 2014
Sub-type Article (original research)
DOI 10.1016/j.tvjl.2014.01.023
Volume 201
Issue 2
Start page 181
End page 183
Total pages 3
Place of publication London, United Kingdom
Publisher Elsevier
Collection year 2015
Language eng
Formatted abstract
Veterinarians have few tools to predict the rate of disease progression in FIV-infected cats. In contrast, in HIV infection, plasma viral RNA load and acute phase protein concentrations are commonly used as predictors of disease progression. This study evaluated these predictors in cats naturally infected with FIV. In older cats (>5 years), log10 FIV RNA load was higher in the terminal stages of disease compared to the asymptomatic stage. There was a significant association between log10 FIV RNA load and both log10 serum amyloid A concentration and age in unwell FIV-infected cats. This study suggests that viral RNA load and serum amyloid A warrant further investigation as predictors of disease status and prognosis in FIV-infected cats.
Keyword Acute phase protein
Feline immunodeficiency virus
FIV
Real-time PCR
Viral load
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Veterinary Science Publications
 
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