Vitamin D as a neurosteroid affecting the developing and adult brain

Groves, Natalie J., McGrath, John J. and Burne, Thomas H. J. (2014) Vitamin D as a neurosteroid affecting the developing and adult brain. Annual Review of Nutrition, 34 117-141. doi:10.1146/annurev-nutr-071813-105557


Author Groves, Natalie J.
McGrath, John J.
Burne, Thomas H. J.
Title Vitamin D as a neurosteroid affecting the developing and adult brain
Journal name Annual Review of Nutrition   Check publisher's open access policy
ISSN 0199-9885
1545-4312
Publication date 2014
Year available 2014
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1146/annurev-nutr-071813-105557
Open Access Status
Volume 34
Start page 117
End page 141
Total pages 25
Place of publication Palo Alto, CA United States
Publisher Annual Reviews Inc.
Collection year 2015
Language eng
Subject 2701 Medicine (miscellaneous)
2916 Nutrition and Dietetics
Abstract Vitamin D deficiency is prevalent throughout the world, and growing evidence supports a requirement for optimal vitamin D levels for the healthy developing and adult brain. Vitamin D has important roles in proliferation and differentiation, calcium signaling within the brain, and neurotrophic and neuroprotective actions; it may also alter neurotransmission and synaptic plasticity. Recent experimental studies highlight the impact that vitamin D deficiency has on brain function in health and disease. In addition, results from recent animal studies suggest that vitamin D deficiency during adulthood may exacerbate underlying brain disorders and or worsen recovery from brain stressors. An increasing number of epidemiological studies indicate that vitamin D deficiency is associated with a wide range of neuropsychiatric disorders and neurodegenerative diseases. Vitamin D supplementation is readily available and affordable, and this review highlights the need for further research. Copyright
Keyword Animal models
Behavior
Brain development
Neurochemistry
Vitamin D
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Queensland Brain Institute Publications
Official 2015 Collection
School of Medicine Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 17 times in Thomson Reuters Web of Science Article | Citations
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