Multifunctional graphene oxide-based triple stimuli-responsive nanotheranostics

Chen, Yu, Xu, Pengfei, Shu, Zhu, Wu, Meiying, Wang, Lianzhou, Zhang, Shengjian, Zheng, Yuanyi, Chen, Hangrong, Wang, Jin, Li, Yaping and Shi, Jianlin (2014) Multifunctional graphene oxide-based triple stimuli-responsive nanotheranostics. Advanced Functional Materials, 24 28: 4386-4396. doi:10.1002/adfm.201400221


Author Chen, Yu
Xu, Pengfei
Shu, Zhu
Wu, Meiying
Wang, Lianzhou
Zhang, Shengjian
Zheng, Yuanyi
Chen, Hangrong
Wang, Jin
Li, Yaping
Shi, Jianlin
Title Multifunctional graphene oxide-based triple stimuli-responsive nanotheranostics
Journal name Advanced Functional Materials   Check publisher's open access policy
ISSN 1616-301X
1616-3028
Publication date 2014-07-23
Sub-type Article (original research)
DOI 10.1002/adfm.201400221
Open Access Status
Volume 24
Issue 28
Start page 4386
End page 4396
Total pages 11
Place of publication Weinheim, Germany
Publisher Wiley-VCH Verlag
Collection year 2015
Language eng
Abstract Construction of multifunctional stimuli-responsive nanosystems intelligently responsive to inner physiological and/or external irradiations based on nanobiotechnology can enable the on-demand drug release and improved diagnostic imaging to mitigate the side-effects of anticancer drugs and enhance the diagnostic/therapeutic outcome simultaneously. Here, a triple-functional stimuli-responsive nanosystem based on the co-integration of superparamagnetic Fe3O4 and paramagnetic MnOx nanoparticles (NPs) onto exfoliated graphene oxide (GO) nanosheets by a novel and efficient double redox strategy (DRS) is reported. Aromatic anticancer drug molecules can interact with GO nanosheets through supramolecular π stacking to achieve high drug loading capacity and pH-responsive drug releasing performance. The integrated MnOx NPs can disintegrate in mild acidic and reduction environment to realize the highly efficient pH-responsive and reduction-triggered T1-weighted magnetic resonance imaging (MRI). Superparamagnetic Fe3O4 NPs can not only function as the T2-weighted contrast agents for MRI, but also response to the external magnetic field for magnetic hyperthermia against cancer. Importantly, the constructed biocompatible GO-based nanoplatform can inhibit the metastasis of cancer cells by downregulating the expression of metastasis-related proteins, and anticancer drug-loaded carrier can significantly reverse the multidrug resistance (MDR) of cancer cells. A triple-functional biocompatible stimuli-responsive nanosystem based on the functionalized nanographene oxides is developed by a novel and efficient double redox strategy. This elaborately designed nanographene oxide-based nanoplatform exhibits the unique triple stimuli-responsivenesses for biomedical engineering, including pH-responsive drug release to inhibit the metastasis and reverse the multidrug resistance of cancer cells, pH-/redox-responsive magnetic resonance imaging and magnetic field-responsive hyperthermia of cancer.
Keyword Cancer therapy
Graphene oxide
Hyperthermia
MRI
Stimuli responsiveness
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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