The association of genotype-based inbreeding coefficient with a range of physical and psychological human traits

Verweij, Karin J. H., Abdellaoui, Abdel, Veijola, Juha, Sebert, Sylvain, Koiranen, Markku, Keller, Matthew C., Jarvelin, Marjo-Ritta and Zietsch, Brendan .P. (2014) The association of genotype-based inbreeding coefficient with a range of physical and psychological human traits. PLoS One, 9 7: e103102.1-e103102.6. doi:10.1371/journal.pone.0103102


Author Verweij, Karin J. H.
Abdellaoui, Abdel
Veijola, Juha
Sebert, Sylvain
Koiranen, Markku
Keller, Matthew C.
Jarvelin, Marjo-Ritta
Zietsch, Brendan .P.
Title The association of genotype-based inbreeding coefficient with a range of physical and psychological human traits
Journal name PLoS One   Check publisher's open access policy
ISSN 1932-6203
Publication date 2014-07-25
Year available 2014
Sub-type Article (original research)
DOI 10.1371/journal.pone.0103102
Open Access Status DOI
Volume 9
Issue 7
Start page e103102.1
End page e103102.6
Total pages 6
Place of publication San Francisco, CA United States
Publisher Public Library of Science
Collection year 2015
Language eng
Abstract Across animal species, offspring of closely related mates exhibit lower fitness, a phenomenon called inbreeding depression. Inbreeding depression in humans is less well understood because mating between close relatives is generally rare and stigmatised, confounding investigation of its effect on fitness-relevant traits. Recently, the availability of high-density genotype data has enabled quantification of variation in distant inbreeding in 'outbred' human populations, but the low variance of inbreeding detected from genetic data in most outbred populations means large samples are required to test effects, and only a few traits have yet been studied. However, it is likely that isolated populations, or those with a small effective population size, have higher variation in inbreeding and therefore require smaller sample sizes to detect inbreeding effects. With a small effective population size and low immigration, Northern Finland is such a population. We make use of a sample of ∼5,500 'unrelated' individuals in the Northern Finnish Birth Cohort 1966 with known genotypes and measured phenotypes across a range of fitness-relevant physical and psychological traits, including birth length and adult height, body mass index (BMI), waist-to-hip ratio, blood pressure, heart rate, grip strength, educational attainment, income, marital status, handedness, health, and schizotypal features. We find significant associations in the predicted direction between individuals' inbreeding coefficient (measured by proportion of the genome in runs of homozygosity) and eight of the 18 traits investigated, significantly more than the one or two expected by chance. These results are consistent with inbreeding depression effects on a range of human traits, but further research is needed to replicate and test alternative explanations for these effects.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Psychology Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 5 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 8 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 12 Aug 2014, 00:23:15 EST by System User on behalf of School of Psychology