Synthesis of vertex-differentiated icosahedral closo -boranes: polyfunctional scaffolds for targeted drug delivery

Goswami, Lalit N., Houston, Zachary H., Sarma, Saurav J., Li, Hairong, Jalisatgi, Satish S. and Hawthorne, M. Frederick (2012) Synthesis of vertex-differentiated icosahedral closo -boranes: polyfunctional scaffolds for targeted drug delivery. Journal of Organic Chemistry, 77 24: 11333-11338. doi:10.1021/jo3021314


Author Goswami, Lalit N.
Houston, Zachary H.
Sarma, Saurav J.
Li, Hairong
Jalisatgi, Satish S.
Hawthorne, M. Frederick
Title Synthesis of vertex-differentiated icosahedral closo -boranes: polyfunctional scaffolds for targeted drug delivery
Journal name Journal of Organic Chemistry   Check publisher's open access policy
ISSN 0022-3263
1520-6904
Publication date 2012-12-21
Sub-type Article (original research)
DOI 10.1021/jo3021314
Open Access Status
Volume 77
Issue 24
Start page 11333
End page 11338
Total pages 6
Place of publication Washington, DC, United States
Publisher American Chemical Society
Language eng
Abstract We report methods for the synthesis of vertex-differentiated icosahedral closo-boranes. A single B-OH vertex of the icosahedral borane [closo-B 12(OH)12]2- was derivatized to prepare [closo-B12(OR)(OH)11]2- using optimized alkylation conditions and purification procedures. Several representative vertex-differentiated icosahedral closo-boranes were prepared utilizing carbonate ester and azide-alkyne click chemistries on the surface of the closo-B12 2- core.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Centre for Advanced Imaging Publications
 
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Created: Mon, 11 Aug 2014, 10:08:16 EST by Zach Houston on behalf of Centre for Advanced Imaging