A convenient route to diversely substituted icosahedral closomer nanoscaffolds

Jalisatgi, Satish S., Kulkarni, Vikas S., Tang, Betty, Houston, Zachary H., Lee Jr., Mark W. and Hawthorne, M. Frederick (2011) A convenient route to diversely substituted icosahedral closomer nanoscaffolds. Journal of the American Chemical Society, 133 32: 12382-12385. doi:10.1021/ja204488p


Author Jalisatgi, Satish S.
Kulkarni, Vikas S.
Tang, Betty
Houston, Zachary H.
Lee Jr., Mark W.
Hawthorne, M. Frederick
Title A convenient route to diversely substituted icosahedral closomer nanoscaffolds
Journal name Journal of the American Chemical Society   Check publisher's open access policy
ISSN 0002-7863
1520-5126
Publication date 2011-08-17
Sub-type Article (original research)
DOI 10.1021/ja204488p
Open Access Status
Volume 133
Issue 32
Start page 12382
End page 12385
Total pages 4
Place of publication Washington, DC, United States
Publisher American Chemical Society
Subject 1600 Chemistry
Abstract The design and synthesis of icosahedral polyhedral borane closomer motifs based upon carbonate and carbamate anchoring groups for biomedical applications are described. Dodecacarbamate closomers containing easily accessible groups of interest at their linker termini were synthesized via activation of the B-OH vertices as aryl carbonates and their subsequent reaction with primary amines. Novel dodecacarbonate closomers were successfully synthesized for the first time by reacting [closo-B 12(OH) 12] 2- with an excess of respective aryl chloroformates, utilizing relatively short reaction times, mild conditions and simple purification strategies, all of which had previously presented difficulties in closomer chemistry. This methodology for the 12-fold degenerate synthesis of carbonate and carbamate closomers will greatly facilitate further exploration of closomers as monodisperse nanomolecular delivery platforms.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Centre for Advanced Imaging Publications
 
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Created: Mon, 11 Aug 2014, 09:49:48 EST by Zach Houston on behalf of Centre for Advanced Imaging