Modulatory mechanisms controlling the NLRP3 inflammasome in inflammation: Recent developments

Haneklaus, Moritz, O'Neill, Luke A. J. and Coll, Rebecca C. (2013) Modulatory mechanisms controlling the NLRP3 inflammasome in inflammation: Recent developments. Current Opinion in Immunology, 25 1: 40-45. doi:10.1016/j.coi.2012.12.004


Author Haneklaus, Moritz
O'Neill, Luke A. J.
Coll, Rebecca C.
Title Modulatory mechanisms controlling the NLRP3 inflammasome in inflammation: Recent developments
Journal name Current Opinion in Immunology   Check publisher's open access policy
ISSN 0952-7915
1879-0372
Publication date 2013
Year available 2013
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.coi.2012.12.004
Open Access Status
Volume 25
Issue 1
Start page 40
End page 45
Total pages 6
Place of publication Kidlington, Oxford, United Kingdom
Publisher Elsevier Ltd. * Current Opinion Journals
Collection year 2013
Language eng
Subject 2723 Immunology and Allergy
2403 Immunology
Abstract The protein NLRP3 has emerged as a central regulator in the inflammatory process, being implicated directly in hereditary cryopyrinopathies, and indirectly in diseases such as gout, Type 2 diabetes and atherosclerosis. NLRP3 is an important regulator of caspase-1, the enzyme that processes the immature form of IL-1β into the active protein. The control of NLRP3 has therefore become a focus of research with evidence for redox regulation, ubiquitination and regulation by miRNA-223, kinases and calcium all emerging as controllers of NLRP3. As our knowledge expands the prospect for precise pharmacological targeting of NLRP3 will improve and could lead to substantial clinical utility.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: Institute for Molecular Bioscience - Publications
 
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