Proton-functionalized two-dimensional graphitic carbon nitride nanosheet: An excellent metal-/label-free biosensing platform

Ma, Tian Yi, Tang, Youhong, Dai, Sheng and Qiao, Shi Zhang (2014) Proton-functionalized two-dimensional graphitic carbon nitride nanosheet: An excellent metal-/label-free biosensing platform. Small, 10 12: 2382-2389. doi:10.1002/smll.201303827


Author Ma, Tian Yi
Tang, Youhong
Dai, Sheng
Qiao, Shi Zhang
Title Proton-functionalized two-dimensional graphitic carbon nitride nanosheet: An excellent metal-/label-free biosensing platform
Journal name Small   Check publisher's open access policy
ISSN 1613-6829
1613-6810
Publication date 2014-06-25
Sub-type Article (original research)
DOI 10.1002/smll.201303827
Open Access Status
Volume 10
Issue 12
Start page 2382
End page 2389
Total pages 8
Place of publication Weinheim Germany
Publisher Wiley-VCH Verlag
Collection year 2015
Language eng
Subject 2502 Biomaterials
2201 Applied Ethics
1305 Biotechnology
Formatted abstract
Ultrathin graphitic carbon nitride (g-C3N4) nanosheets, due to their interesting two-dimensional graphene-like structure and unique physicochemical properties, have attracted great research attention recently. Here, a new approachis developed to prepare, for the first time, proton-functionalized ultrathin g-C3N4 nanosheets by sonication-exfoliation of bulk g-C3N4 under an acid condition. This method not only reduces the exfoliation time from more than 10 h to 2 h, but also endows the nanosheets with positive charges. Besides retaining the properties of g-C3N4, the obtained nanosheets with the thickness of 2-4 nm (i.e., 6-12 atomic monolayers) also exhibit large specific surface area of 305 m2 g-1, enhanced fluorescence intensity, and excellent water dispersion stability due to their surface protonation and ultrathin morphology. The well-dispersed protonated g-C 3N4 nanosheets are able to interact with negatively charged heparin, which results in the quenching of g-C3N4 fluorescence. A highly sensitive and highly selective heparin sensing platform based on protonated g-C3N4 nanosheets is established. This metal-free and fluorophore label-free system can reach the lowest heparin detection limit of 18 ng mL-1. Proton-functionalized g-C 3N4 ultrathin nanosheets with positively charged surface are synthesized by liquid exfoliating acidified bulk g-C3N 4. The obtained g-C3N4 nanosheets with 6-12 atomic monolayers and large surface area up to 305 m2 g-1 exhibit outstanding sensitivity and selectivity in the fluorescence-quenching sensing of heparin under both ideal and physiological conditions.
Keyword Biosensing
Carbon nitride
Fluorescence
Heparin
Nanosheets
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
Australian Institute for Bioengineering and Nanotechnology Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 66 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 75 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Fri, 08 Aug 2014, 18:41:54 EST by System User on behalf of Aust Institute for Bioengineering & Nanotechnology