Intracellular microenvironment responsive polymers: A multiple-stage transport platform for high-performance gene delivery

Shi, Bingyang, Zhang, Hu, Dai, Sheng, Du, Xin, Bi, Jingxiu and Qiao, Shi Zhang (2014) Intracellular microenvironment responsive polymers: A multiple-stage transport platform for high-performance gene delivery. Small, 10 5: 871-877. doi:10.1002/smll.201302430


Author Shi, Bingyang
Zhang, Hu
Dai, Sheng
Du, Xin
Bi, Jingxiu
Qiao, Shi Zhang
Title Intracellular microenvironment responsive polymers: A multiple-stage transport platform for high-performance gene delivery
Journal name Small   Check publisher's open access policy
ISSN 1613-6810
1613-6829
Publication date 2014-03-12
Year available 2013
Sub-type Article (original research)
DOI 10.1002/smll.201302430
Open Access Status
Volume 10
Issue 5
Start page 871
End page 877
Total pages 7
Place of publication Weinheim Germany
Publisher Wiley - V C H Verlag GmbH & Co. KGaA
Collection year 2015
Language eng
Abstract A new strategy for promoting endoplasmic gene delivery and nucleus uptake is proposed by developing intracellular microenvironment responsive biocompatible polymers. This delivery system can efficiently load and self-assemble nucleic acids into nano-structured polyplexes at a neutral pH, release smaller imidazole-gene complexes from the polymer backbones at intracellular endosomal pH, transport nucleic acids into nucleus through intracellular environment responsive multiple-stage gene delivery, thus leading to a high cell transfection efficiency.
Keyword Controlled gene release
Intracellular microenvironment responsive
Multiple-stage gene delivery
Nucleus uptake
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
Australian Institute for Bioengineering and Nanotechnology Publications
 
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