Label-free dendrimer-like silica nanohybrids for traceable and controlled gene delivery

Du, Xin, Shi, Bingyang, Tang, Youhong, Dai, Sheng and Qiao, Shi Zhang (2014) Label-free dendrimer-like silica nanohybrids for traceable and controlled gene delivery. Biomaterials, 35 21: 5580-5590. doi:10.1016/j.biomaterials.2014.03.051

Author Du, Xin
Shi, Bingyang
Tang, Youhong
Dai, Sheng
Qiao, Shi Zhang
Title Label-free dendrimer-like silica nanohybrids for traceable and controlled gene delivery
Journal name Biomaterials   Check publisher's open access policy
ISSN 1878-5905
Publication date 2014-07
Sub-type Article (original research)
DOI 10.1016/j.biomaterials.2014.03.051
Open Access Status
Volume 35
Issue 21
Start page 5580
End page 5590
Total pages 11
Place of publication Amsterdam Netherlands
Publisher Elsevier BV
Collection year 2015
Language eng
Subject 2502 Biomaterials
1502 Banking, Finance and Investment
2503 Ceramics and Composites
2211 Mechanics of Materials
1304 Biophysics
Formatted abstract
To create advanced functional nanocarriers for achieving excellent gene delivery performance, fluorescence label-free hybridized dendrimer-like silica nanocarriers (HPSNs-AC-PEI) were developed by using the endosomal pH and cytoplasmic glutathione (GSH) responsive autofluorescent acetaldehyde-modified-cystine (AC) to link non-toxic low molecular weight branched polyethyleneimine (PEI) onto amino-functionalized dendrimer-like silica nanoparticles with hierarchical pores (HPSNs-NH2). The specific microstructure of this hybridized nanocarrier makes it not only show low cytotoxicity and high gene loading capability, but also display high gene transfection efficiency. The cleavage of disulfide bonds caused by GSH facilitates plasmid DNA (pDNA) release. Moreover, the pH and GSH controlled gene delivery profile can be real-time tracked using the autofluorescence of HPSNs-AC-PEI.
Keyword Dendrimer-like
Gene delivery
Mesoporous silica
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
Australian Institute for Bioengineering and Nanotechnology Publications
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Created: Fri, 08 Aug 2014, 18:22:50 EST by System User on behalf of Aust Institute for Bioengineering & Nanotechnology