Identification and preliminary characterization of novel B3-type metallo-beta-lactamases

Miraula, Manfredi, Brunton, Conor S., Schenk, Gerhard and Mitić, Nataša (2013) Identification and preliminary characterization of novel B3-type metallo-beta-lactamases. American Journal of Molecular Biology, 3 4: 198-203. doi:10.4236/ajmb.2013.34026


Author Miraula, Manfredi
Brunton, Conor S.
Schenk, Gerhard
Mitić, Nataša
Title Identification and preliminary characterization of novel B3-type metallo-beta-lactamases
Formatted title
Identification and preliminary characterization of novel B3-type metallo-β-lactamases
Journal name American Journal of Molecular Biology   Check publisher's open access policy
ISSN 2161-6620
2161-6663
Publication date 2013-10-18
Sub-type Article (original research)
DOI 10.4236/ajmb.2013.34026
Open Access Status DOI
Volume 3
Issue 4
Start page 198
End page 203
Total pages 6
Place of publication Irvine, CA, United States
Publisher Scientific Research Publishing
Language eng
Formatted abstract
Antibiotic resistance has emerged as a major global threat to human health. Among the strategies employed by pathogens to acquire resistance the use of metallo-β-lactamases (MBLs), a family of dinuclear metalloenzymes, is among the most potent. MBLs are subdivided into three groups (i.e. B1, B2 and B3) with most of the virulence factors belonging to the B1 group. The recent discovery of AIM-1, a B3-type MBL, however, has illustrated the potential health threat of this group of MBLs. Here, we employed a bioinformatics approach to identify and characterize novel B3-type MBLs from Novosphingobium pentaromativorans and Simiduia agarivorans. These enzymes may not yet pose a direct risk to human health, but their structures and function may provide important insight into the design and synthesis of a still elusive universal MBL inhibitor.
Keyword Antibiotic resistance
β-Lactam antibiotics
Metallo-β-lactamases
Sequence homology
Novosphingobium pentaromativorans
Simiduia agarivorans
beta-Lactam antibiotics
Metallo-beta-lactamases
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Chemistry and Molecular Biosciences
 
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Created: Thu, 07 Aug 2014, 14:19:11 EST by Associate Professor Gary Schenk on behalf of School of Chemistry & Molecular Biosciences