Chemical attenuation of pilus function and assembly in Gram-negative bacteria

Lo, Alvin W. H., Moonens, Kristof and Remaut, Han (2013) Chemical attenuation of pilus function and assembly in Gram-negative bacteria. Current Opinion in Microbiology, 16 1: 85-92. doi:10.1016/j.mib.2013.02.003


Author Lo, Alvin W. H.
Moonens, Kristof
Remaut, Han
Title Chemical attenuation of pilus function and assembly in Gram-negative bacteria
Journal name Current Opinion in Microbiology   Check publisher's open access policy
ISSN 1369-5274
1879-0364
Publication date 2013
Year available 2013
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.mib.2013.02.003
Open Access Status
Volume 16
Issue 1
Start page 85
End page 92
Total pages 8
Place of publication Kidlington, Oxford, United Kingdom
Publisher Elsevier Ltd. * Current Opinion Journals
Collection year 2013
Language eng
Subject 2725 Infectious Diseases
2726 Microbiology (medical)
2404 Microbiology
Abstract Bacteria express a multitude of hair-like adhesive appendages on their cell surfaces, together referred to as pili or fimbriae. In Gram-negative bacteria, these proteinaceous structures are assembled through a number of dedicated secretion pathways including the chaperone-usher pathway, the nucleation/precipitation pathway and the type IV pilus pathway. Pili are prevalent in pathogenic strains and play important roles in the establishment and persistence of bacterial infections by mediating host cell adhesion, cell invasion or biofilm formation. Their indispensible roles in pathogenesis render them attractive targets for directed therapeutic intervention. Here, we describe the recent advances in the chemical attenuation of pilus-associated virulence in Gram-negative bacteria.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Chemistry and Molecular Biosciences
 
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Created: Thu, 07 Aug 2014, 12:48:45 EST by Ms Kate Rowe on behalf of School of Chemistry & Molecular Biosciences