Effect of whole-body mild-cold exposure on arterial stiffness and central haemodynamics: A randomised, cross-over trial in healthy men and women

King, Sibella G., Ahuja, Kiran D. K., Wass, Jezreel, Shing, Cecilia M., Adams, Murray J., Davies, Justin E., Sharman, James E. and Williams, Andrew D. (2013) Effect of whole-body mild-cold exposure on arterial stiffness and central haemodynamics: A randomised, cross-over trial in healthy men and women. European Journal of Applied Physiology, 113 5: 1257-1269. doi:10.1007/s00421-012-2543-1


Author King, Sibella G.
Ahuja, Kiran D. K.
Wass, Jezreel
Shing, Cecilia M.
Adams, Murray J.
Davies, Justin E.
Sharman, James E.
Williams, Andrew D.
Title Effect of whole-body mild-cold exposure on arterial stiffness and central haemodynamics: A randomised, cross-over trial in healthy men and women
Journal name European Journal of Applied Physiology   Check publisher's open access policy
ISSN 1439-6319
1439-6327
Publication date 2013
Year available 2013
Sub-type Article (original research)
DOI 10.1007/s00421-012-2543-1
Open Access Status
Volume 113
Issue 5
Start page 1257
End page 1269
Total pages 13
Place of publication Heidelberg, Germany
Publisher Springer
Collection year 2014
Language eng
Subject 2739 Public Health, Environmental and Occupational Health
2732 Orthopedics and Sports Medicine
2737 Physiology (medical)
Abstract Aortic pulse wave velocity (PWV) and augmentation index (AIx) are independent predictors of cardiovascular risk and mortality, but little is known about the effect of air temperature changes on these variables. Our study investigated the effect of exposure to whole-body mild-cold on measures of arterial stiffness (aortic and brachial PWV), and on central haemodynamics [including augmented pressure (AP), AIx], and aortic reservoir components [including reservoir and excess pressures (P ex)]. Sixteen healthy volunteers (10 men, age 43 ± 19 years; mean ± SD) were randomised to be studied under conditions of 12 C (mild-cold) and 21 C (control) on separate days. Supine resting measures were taken at baseline (ambient temperature) and after 10, 30, and 60 min exposure to each experimental condition in a climate chamber. There was no significant change in brachial blood pressure between mild-cold and control conditions. However, compared to control, AP [+2 mmHg, 95 % confidence interval (CI) 0.36-4.36; p = 0.01] and AIx (+6 %, 95 % CI 1.24-10.1; p = 0.02) increased, and time to maximum P ex (a component of reservoir function related to timing of peak aortic in-flow) decreased (-7 ms, 95 % CI -15.4 to 2.03; p = 0.01) compared to control. Yet there was no significant change in aortic PWV (+0.04 m/s, 95 % CI -0.47 to 0.55; p = 0.87) or brachial PWV (+0.36 m/s; -0.41 to 1.12; p = 0.35) between conditions. We conclude that mild-cold exposure increases central haemodynamic stress and alters timing of peak aortic in-flow without differentially affecting arterial stiffness.
Keyword Aortic reservoir function
Augmentation index
Central blood pressure
Climate
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Human Movement and Nutrition Sciences Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 2 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 2 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Thu, 07 Aug 2014, 12:19:03 EST by System User on behalf of School of Human Movement and Nutrition Sciences