Hypolipidaemic effect of crude extract from Carpobrotus rossii (pigface) in healthy rats

Pirie, Adam D., Davies, Noel W., Ahuja, Kiran D.K., Adams, Murray J., Shing, Cecilia M., Narkowicz, Christian, Jacobson, Glenn A. and Geraghty, Dominic P. (2014) Hypolipidaemic effect of crude extract from Carpobrotus rossii (pigface) in healthy rats. Food and Chemical Toxicology, 66 134-139. doi:10.1016/j.fct.2014.01.034

Author Pirie, Adam D.
Davies, Noel W.
Ahuja, Kiran D.K.
Adams, Murray J.
Shing, Cecilia M.
Narkowicz, Christian
Jacobson, Glenn A.
Geraghty, Dominic P.
Title Hypolipidaemic effect of crude extract from Carpobrotus rossii (pigface) in healthy rats
Journal name Food and Chemical Toxicology   Check publisher's open access policy
ISSN 0278-6915
Publication date 2014-04
Sub-type Article (original research)
DOI 10.1016/j.fct.2014.01.034
Open Access Status
Volume 66
Start page 134
End page 139
Total pages 6
Place of publication Kidlington, United Kingdom
Publisher Pergamon Press
Collection year 2015
Language eng
Subject 1106 Human Movement and Sports Science
3005 Toxicology
Formatted abstract
Carpobrotus rossii (CR) was used by the Aboriginal population and early European settlers both as a food and therapeutic agent. Based on the presence of flavonoids in CR and results from our previous in vitro investigations. , this study aimed to determine whether consumption of CR crude leaf extract: (a) affected lipoprotein profile, resting glucose, systolic blood pressure and vascular function, and (b) produced toxic effects (haematological measures, organ weight) in healthy rats. Male Hooded-Wistar rats (~230. g) were supplemented for 4. weeks with CR extract in their drinking water (35. mg/kg body weight daily). CR extract produced a significant decrease (18%, p=. 0.033) in atherogenic lipoproteins (but not high density lipoprotein). CR supplemented animals showed no signs of haematological toxicity and body and organ weight, daily fluid and food consumption and in vitro vascular responsiveness were similar for both groups. CR also increased (40%, p=. 0.049) the renal concentration of 3-hydroxy-3-methylglutaric acid (HMG), consistent with HMG-containing CR flavonoids being bioavailable, and therefore possessing the potential to interfere with cholesterol synthesis pathways. CR extract appears to be safe to ingest and may reduce cardiovascular risk.
Keyword Cardiovascular
Carpobrotus spp
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
School of Human Movement and Nutrition Sciences Publications
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