Investigation of homocysteine-pathway-related variants in essential hypertension.

Fowdar, Javed Y., Larson, Marta V., Szvetko, Attila L., Lea, Rodney A. and Griffiths, Lyn R. (2012) Investigation of homocysteine-pathway-related variants in essential hypertension.. International Journal of Hypertension, 2012 1-9. doi:10.1155/2012/190923

Author Fowdar, Javed Y.
Larson, Marta V.
Szvetko, Attila L.
Lea, Rodney A.
Griffiths, Lyn R.
Title Investigation of homocysteine-pathway-related variants in essential hypertension.
Journal name International Journal of Hypertension   Check publisher's open access policy
ISSN 2090-0384
Publication date 2012
Sub-type Article (original research)
DOI 10.1155/2012/190923
Open Access Status DOI
Volume 2012
Start page 1
End page 9
Total pages 9
Place of publication New York, United States
Publisher Hindawi Publishing Corporation
Language eng
Abstract Hyperhomocysteinemia (hHcy) has been associated with an increased risk of cardiovascular disease and stroke. Essential hypertension (EH), a polygenic condition, has also been associated with increased risk of cardiovascular related disorders. To investigate the role of the homocysteine (Hcy) metabolism pathway in hypertension we conducted a case-control association study of Hcy pathway gene variants in a cohort of Caucasian hypertensives and age- and sex-matched normotensives. We genotyped two polymorphisms in the methylenetetrahydrofolate reductase gene (MTHFR C677T and MTHFR A1298C), one polymorphism in the methionine synthase reductase gene (MTRR A66G), and one polymorphism in the methylenetetrahydrofolate dehydrogenase 1 gene (MTHFD1 G1958A) and assessed their association with hypertension using chi-square analysis. We also performed a multifactor dimensionality reduction (MDR) analysis to investigate any potential epistatic interactions among the four polymorphisms and EH. None of the four polymorphisms was significantly associated with EH and although we found a moderate synergistic interaction between MTHFR A1298C and MTRR A66G, the association of the interaction model with EH was not statistically significant (). Our findings therefore suggest no individual or interactive association between four prominent Hcy pathway markers and EH.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Article ID 190923.

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Brain Institute Publications
Version Filter Type
Citation counts: Scopus Citation Count Cited 16 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Thu, 07 Aug 2014, 12:12:28 EST by Debra McMurtrie on behalf of Queensland Brain Institute