Renal cell neoplasms of oncocytosis have distinct morphologic, immunohistochemical, and cytogenetic profiles

Gobbo, Stefano, Eble, John N., Delahunt, Brett, Grignon, David J., Samaratunga, Hemamali, Martignoni, Guido, Zhang, Shaobo, Wang, Mingsheng, Brunelli, Matteo, Cossu-Rocca, Paolo and Cheng, Liang (2010) Renal cell neoplasms of oncocytosis have distinct morphologic, immunohistochemical, and cytogenetic profiles. American Journal of Surgical Pathology, 34 5: 620-626. doi:10.1097/PAS.0b013e3181d73293


Author Gobbo, Stefano
Eble, John N.
Delahunt, Brett
Grignon, David J.
Samaratunga, Hemamali
Martignoni, Guido
Zhang, Shaobo
Wang, Mingsheng
Brunelli, Matteo
Cossu-Rocca, Paolo
Cheng, Liang
Title Renal cell neoplasms of oncocytosis have distinct morphologic, immunohistochemical, and cytogenetic profiles
Journal name American Journal of Surgical Pathology   Check publisher's open access policy
ISSN 0147-5185
1532-0979
Publication date 2010
Year available 2010
Sub-type Article (original research)
DOI 10.1097/PAS.0b013e3181d73293
Open Access Status
Volume 34
Issue 5
Start page 620
End page 626
Total pages 7
Place of publication Philadelphia, PA United States
Publisher Lippincott Williams and Wilkins
Collection year 2011
Language eng
Subject 2702 Anatomy
2734 Pathology and Forensic Medicine
2746 Surgery
Abstract This study was undertaken to elucidate the genetic patterns of the renal cell neoplasms of oncocytosis and to compare them with those found in cases with multiple oncocytomas. Three cases of renal oncocytosis and 6 cases of multiple oncocytomas were analyzed. Fluorescence in situ hybridization analysis was performed with centromeric probes for chromosomes 1, 2, 6, 10, and 17 that are typically lost in chromophobe renal cell carcinoma but not in oncocytoma. Immunohistochemistry for cytokeratin 7, parvalbumin, and S100A1 was performed in all cases. Eleven tumors were present in the 3 kidneys with oncocytosis. One of these was a classic chromophobe renal cell carcinoma. In the other 10, none showed any chromosomal losses, whereas 3 showed gains of all 5 chromosomes and 1 had gains of chromosomes 2 and 10. The chromophobe renal cell carcinoma showed losses of chromosome 1, 6, 10, and 17. Twelve of 14 tumors from the patients with multiple oncocytomas showed no loss of any of the chromosomes 1, 2, 6, 10, or 17 and 2 had loss of chromosome 1. All the tumors from kidneys with renal oncocytosis showed strong parvalbumin immunoreactivity, whereas cytokeratin 7 and S100A1 expression were variable. In summary, the renal cell neoplasms of oncocytosis seem to have distinct morphologic, immunohistochemical, and cytogenetic profiles and likely are a distinct entity, not closely related to oncocytoma or chromophobe renal cell carcinoma.
Keyword Chromophobe
Cytogenetic
Fluorescence in situ hybridization
Hybrid
Immunohistochemistry
Kidney
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Health and Rehabilitation Sciences Publications
 
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