Significance of Minute Focus of Adenocarcinoma on Prostate Needle Biopsy

Samaratunga H., Yaxley J., Kerr K., McClymont K. and Duffy D. (2007) Significance of Minute Focus of Adenocarcinoma on Prostate Needle Biopsy. Urology, 70 2: 299-302. doi:10.1016/j.urology.2007.03.068

Author Samaratunga H.
Yaxley J.
Kerr K.
McClymont K.
Duffy D.
Title Significance of Minute Focus of Adenocarcinoma on Prostate Needle Biopsy
Journal name Urology   Check publisher's open access policy
ISSN 0090-4295
Publication date 2007
Sub-type Article (original research)
DOI 10.1016/j.urology.2007.03.068
Volume 70
Issue 2
Start page 299
End page 302
Total pages 4
Language eng
Subject 2748 Urology
Abstract Objectives: To assess the radical prostatectomy findings in patients with a minute focus of adenocarcinoma on prostate needle biopsy in current practice in Australia. Methods: A total of 58 patients with a 0.5-mm focus or less of Gleason score 6 adenocarcinoma on needle biopsy who had been treated by radical prostatectomy were selected. At each biopsy, 6 to 20 cores (mean 11, median 13) were taken. Significant tumors were those with a Gleason score of 6 or more and tumor volume of 0.5 cm 3 or larger. Results: The 58 patients (mean age 50 years, median 58, range 44 to 69) had a mean prostate-specific antigen (PSA) level of 6.9 ng/mL (range 0.7 to 16, median 6). Of the 58 men, 48 (82.75%) had pathologically significant tumor, with 8 (13.8%) showing extraprostatic extension. No statistically significant association was found between significant carcinoma and age, mean PSA level, PSA density greater than 0.15, prior negative biopsy, coexistent atypical glands, or the number of tissue cores per biopsy. A prostate weight greater than 40 g correlated significantly with insignificant cancer on both univariate (P = 0.03) and multivariate (P = 0.02) analyses. In 14 (29.2%) of 48 patients with significant tumor, the largest cancer focus in the radical prostatectomy was anterior, lateral, or anterolateral. In patients without atypical glands, 37 (78.72%) of 47 had significant carcinoma, a risk not significantly lower than that of the entire group. Conclusions: The results of our study have shown that in populations without PSA screening, a minute focus of prostate cancer on needle biopsy, even with extended biopsy cores, does not mean insignificant carcinoma in most cases. Patients with larger glands had a greater chance of insignificant cancer.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
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